Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.72 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.72 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.72 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.68 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.68 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | XBP1 | P17861 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20870704 | 0.84 | EPHX2 (0.70) | EPHX2TRPV1MAPTHTTNPC1 | |
| SCHEMBL2611231 | 0.84 | L3MBTL1 (0.79) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL14466017 | 0.81 | KIF11 (0.66) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL22117046 | 0.81 | TRPV1 (0.70) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL13002990 | 0.80 | MAPT (0.59) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL5546929 | 0.80 | HDAC1 (0.67) | MAPTHTTNPC1RAB9AMEN1 | |
| SCHEMBL2730172 | 0.79 | MAPT (0.81) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL13756246 | 0.79 | MAPT (0.81) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL2079990 | 0.79 | SMN1; SMN2 (0.69) | PDK1PDK2PDK3PDK4EPHX2 | |
| SCHEMBL13154802 | 0.79 | L3MBTL1 (0.66) | MAPTHTTRAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200172473-A1 | DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE | JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN (DE) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172473-A1 | DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE | NR1H4, NR1H3, NR1H2 | PDK1 1850/4885PDK2 2566/4885PDK3 1701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.