Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.59 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.59 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.59 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22059482 | 0.85 | ERCC1 (0.59) | NR1H4ERCC1ERCC4CARM1PRMT6 | |
| SCHEMBL22060011 | 0.84 | NR1H4 (0.59) | NR1H4ERCC1ERCC4PTGESAPEX1 | |
| SCHEMBL5357073 | 0.83 | NR1H4 (0.63) | NR1H4EPHX2HDAC1KMT2ARARB | |
| SCHEMBL14782824 | 0.81 | PTGES (0.59) | NR1H4ERCC1ERCC4PTGESAPEX1 | |
| SCHEMBL29463256 | 0.81 | PTGES (0.59) | NR1H4ERCC1ERCC4PTGESAPEX1 | |
| SCHEMBL9931138 | 0.79 | PTGES (0.61) | NR1H4ERCC1ERCC4EPHX2HDAC1 | |
| SCHEMBL29030199 | 0.79 | NR1H4 (0.58) | NR1H4EPHX2KMT2ARARB | |
| SCHEMBL4562855 | 0.79 | KMT2A (0.66) | NR1H4ERCC1ERCC4EPHX2HDAC1 | |
| SCHEMBL1067954 | 0.79 | NR1H4 (0.59) | NR1H4EPHX2KMT2ARARBAPEX1 | |
| SCHEMBL18251691 | 0.78 | ERCC1 (0.77) | ERCC1ERCC4CARM1PRMT6PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200172473-A1 | DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE | JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN (DE) | 2020-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200172473-A1 | DUAL MODULATORS OF FARNESOID X RECEPTOR AND SOLUBLE EPOXIDE HYDROLASE | NR1H4, NR1H3, NR1H2 | NR1H4 1/4885ERCC1 2685/4885ERCC4 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.