Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 13/20 | 0.59 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.57 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29463256 | 1.00 | PTGES (0.59) | PTGESERCC1ERCC4TSHRAPEX1 | |
| SCHEMBL22060011 | 0.88 | NR1H4 (0.59) | PTGESERCC1ERCC4TSHRAPEX1 | |
| SCHEMBL14782792 | 0.86 | PTGES (0.57) | PTGESERCC1ERCC4TSHR | |
| SCHEMBL18810338 | 0.85 | PTGES (0.56) | PTGESERCC1ERCC4TSHR | |
| SCHEMBL8310378 | 0.84 | TSHR (0.66) | PTGESERCC1ERCC4TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL20489719 | 0.83 | PTGES (0.55) | PTGESERCC1ERCC4TSHR | |
| Hydrochloric Acid SCHEMBL29416936 | 0.83 | PTGES (0.55) | PTGESERCC1ERCC4TSHR | |
| SCHEMBL20149739 | 0.83 | KMT2A (0.56) | TSHRAPEX1NR1H4ALDH1A1TP53 | |
| SCHEMBL14782706 | 0.83 | HPGD (0.55) | PTGESTSHRAPEX1NR1H4ALDH1A1 | |
| SCHEMBL14816996 | 0.83 | ALDH1A1 (0.52) | TSHRAPEX1NR1H4ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013038308-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-03-21 | — | — | WO | claimed |
| US-12465588-B2 | Indole carboxamide derivative and pharmaceutical composition containing same | KUKJE PHARMA CO., LTD. (KR) | 2025-11-11 | — | — | US | disclosed |
| US-20230000821-A1 | INDOLE CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KUKJE PHARMA CO., LTD. (KR) | 2023-01-05 | — | — | US | disclosed |
| US-20230000821-A1 | INDOLE CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KUKJE PHARMA CO., LTD. (KR) | 2023-01-05 | — | — | US | disclosed |
| EP-4023638-A1 | INDOLE CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Kukje Pharma Co., Ltd. (KR) | 2022-07-06 | — | — | EP | disclosed |
| CN-114302874-A | Indole carboxamide derivatives and pharmaceutical compositions comprising same | 国际药品株式会社 | 2022-04-08 | — | — | CN | disclosed |
| WO-2021040393-A1 | INDOLE CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 국제약품 주식회사 | 2021-03-04 | — | — | WO | disclosed |
| WO-2021040393-A1 | INDOLE CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 국제약품 주식회사 | 2021-03-04 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2013038308-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12465588-B2 | Indole carboxamide derivative and pharmaceutical composition containing same | PTGES, PTGES2, PTGS1 | PTGES 1/4885ERCC1 4579/4885ERCC4 4685/4885 |
| US-20230000821-A1 | INDOLE CARBOXAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | PTGES, PTGES2, PTGS1 | PTGES 1/4885ERCC1 4579/4885ERCC4 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.