Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.58 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA4 | P22748 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 2/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595617 | 0.80 | ALDH1A1 (0.67) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL30149949 | 0.80 | ALDH1A1 (0.67) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL22079249 | 0.78 | PSMB8 (0.58) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL27623701 | 0.77 | PSMB8 (0.50) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL28689333 | 0.77 | PSMB8 (0.57) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL9439692 | 0.77 | ALDH1A1 (0.56) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL2754297 | 0.76 | PSMB8 (0.70) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL2711265 | 0.76 | PSMB8 (0.75) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL30179604 | 0.75 | PSMB8 (0.58) | PSMB8PSMB5CA12CA1CA2 | |
| SCHEMBL28332572 | 0.75 | PSMB8 (0.58) | PSMB8PSMB5CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106727147-B | Draft American ginseng beautifying skin improves drug and cosmetic applications and preparation | 首都医科大学附属北京中医医院 | 2019-11-15 | — | — | CN | disclosed |
| CN-106727147-A | Draft American ginseng beautifying skin improves medicine and cosmetic applications and preparation | 首都医科大学附属北京中医医院 | 2017-05-31 | — | — | CN | disclosed |
| EP-1926721-B1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | MSD ITALIA SRL (IT) | 2016-05-04 | — | — | EP | disclosed |
| US-7977374-B2 | Thiophene and thiazole substituted trifluoroethanone derivatives as histone deacetylase (HDAC) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-07-12 | — | — | US | disclosed |
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
| EP-1926721-A2 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007029035-A2 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |
| EP-0625551-B1 | Mixtures of dyes, process for their preparation and the use thereof | CIBA GEIGY AG (CH) | 1999-09-29 | — | — | EP | disclosed |
| EP-0631008-B1 | Process for the washing of printings or dyeings on cellulose containing textile materials | CIBA GEIGY AG (CH) | 1999-08-18 | — | — | EP | disclosed |
| EP-0625549-B1 | Reactive dyes, process for their preparation and the use thereof | CIBA GEIGY AG (CH) | 1998-07-01 | — | — | EP | disclosed |
| EP-0485336-B1 | Mixtures of reactive dyes, process for their preparation and their utilization | CIBA GEIGY AG (CH) | 1997-03-26 | — | — | EP | disclosed |
| EP-0613400-A1 | TEST DEVICE COMPRISING A PLATE CONTAINING A MULTIPLICITY OF WELLS WITH AN ASSOCIATED METERING DEVICE, AS WELL AS A KIT WHICH COMPRISES THESE DEVICES AND USE OF THE DEVICES. | SEED CAPITAL INVESTMENTS (NL) | 1994-09-07 | — | — | EP | disclosed |
| WO-1993009872-A1 | TEST DEVICE COMPRISING A PLATE CONTAINING A MULTIPLICITY OF WELLS WITH AN ASSOCIATED METERING DEVICE, AS WELL AS A KIT WHICH COMPRISES THESE DEVICES AND USE OF THE DEVICES | SEED CAPITAL INVESTMENTS (SCI) B.V. (NL) | 1993-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156591-A1 | Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors | HDAC1, HDAC2, HDAC11 | PSMB8 3123/4885PSMB5 1551/4885CA12 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.