Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23008904 | 0.98 | ALDH1A1 (0.49) | ALDH1A1EPHX1SMN1; SMN2PSMB5USP2 | |
| SCHEMBL19248304 | 0.86 | EPHX1 (0.57) | EPHX1SMN1; SMN2HSD17B10NAAAHDAC8 | |
| SCHEMBL19852871 | 0.86 | EPHX1 (0.57) | EPHX1SMN1; SMN2HSD17B10NAAAHDAC8 | |
| SCHEMBL15059606 | 0.84 | KMT2A (0.55) | ALDH1A1EPHX1SMN1; SMN2USP2HSD17B10 | |
| SCHEMBL19142955 | 0.80 | KMT2A (0.55) | ALDH1A1EPHX1SMN1; SMN2USP2HSD17B10 | |
| SCHEMBL23008410 | 0.79 | PSMB5 (0.51) | ALDH1A1EPHX1SMN1; SMN2PSMB5USP2 | |
| SCHEMBL18850117 | 0.77 | EPHX1 (0.52) | ALDH1A1EPHX1SMN1; SMN2PSMB5USP2 | |
| SCHEMBL18850256 | 0.77 | EPHX1 (0.52) | ALDH1A1EPHX1SMN1; SMN2PSMB5USP2 | |
| SCHEMBL19289784 | 0.77 | NAAA (0.53) | ALDH1A1EPHX1SMN1; SMN2PSMB5USP2 | |
| SCHEMBL19289561 | 0.77 | EPHX1 (0.52) | ALDH1A1EPHX1SMN1; SMN2PSMB5USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189056-B1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN INC (US) | 2020-06-10 | — | — | EP | disclosed |