Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19248304 | 1.00 | EPHX1 (0.57) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL15059606 | 0.98 | KMT2A (0.55) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL19142955 | 0.94 | KMT2A (0.55) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL23008904 | 0.87 | ALDH1A1 (0.49) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL22064136 | 0.86 | ALDH1A1 (0.48) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL25973060 | 0.85 | EPHX1 (0.46) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL3184451 | 0.82 | NAAA (0.66) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL3364953 | 0.82 | EPHX1 (0.55) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL11015380 | 0.82 | KMT2A (0.81) | EPHX1KMT2AHDAC6SMN1; SMN2HDAC8 | |
| SCHEMBL28042554 | 0.82 | KMT2A (0.57) | EPHX1KMT2ASMN1; SMN2HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018027022-A1 | COMBINATION OF PROTEASOME INHIBITORS AND ANTI-CD30 ANTIBODIES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-02-08 | — | — | WO | disclosed |