Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | FURIN | P09958 | 1/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.35 |
| ▸ | SDCBP | O00560 | 1/20 | 0.35 |
| ▸ | SDC2 | P34741 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22064353 | 0.87 | CTSS (0.43) | CTSSCTSKRECQLFURINCAPN1 | |
| SCHEMBL22987335 | 0.86 | RECQL (0.46) | RECQLCAPN1TSHRBIRC2ALDH1A1 | |
| SCHEMBL19656347 | 0.83 | PSENEN (0.40) | CTSSCTSKRECQLTSHRCA2 | |
| SCHEMBL25908085 | 0.83 | PSENEN (0.40) | CTSSCTSKRECQLTSHRCA2 | |
| SCHEMBL464264 | 0.80 | CTSS (0.43) | CTSSCTSKCA2CA1CA7 | |
| SCHEMBL19471807 | 0.80 | RECQL (0.69) | RECQLTSHRCA2ALDH1A1LMNA | |
| SCHEMBL22508225 | 0.78 | RECQL (0.39) | RECQLTSHRALDH1A1LMNA | |
| SCHEMBL4470428 | 0.77 | CTSK (0.67) | CTSSCTSKCA2CA1CA7 | |
| SCHEMBL9788528 | 0.77 | CTSK (0.67) | CTSSCTSKCA2CA1CA7 | |
| SCHEMBL22960908 | 0.77 | CTSK (0.59) | CTSSCTSKCAPN1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778601-A1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | ImmunoGen, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3189056-B1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN INC (US) | 2020-06-10 | — | — | EP | disclosed |