Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.52 |
| ▸ | DRD4 | P21917 | 8/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19428179 | 0.83 | ROCK1 (0.61) | DRD2DRD4ALDH1A1MEN1ADRA1D | |
| SCHEMBL19428052 | 0.80 | XIAP (0.55) | DRD2DRD4ALDH1A1MEN1ADRA1D | |
| SCHEMBL23300477 | 0.78 | NOTUM (0.43) | DRD2DRD4MEN1ADRA1DADRA1A | |
| SCHEMBL22065958 | 0.78 | DRD2 (0.55) | DRD2DRD4ALDH1A1MEN1ADRA1D | |
| SCHEMBL23870662 | 0.76 | DRD4 (0.49) | DRD2DRD4ALDH1A1MEN1ADRA1D | |
| SCHEMBL26600961 | 0.76 | DRD2 (0.48) | DRD2DRD4ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL19427956 | 0.74 | HTR2C (0.51) | KMT2ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL19411076 | 0.72 | LMNA (0.47) | DRD2DRD4ALDH1A1KMT2APOLB | |
| SCHEMBL22065608 | 0.70 | DRD4 (0.41) | DRD2DRD4ALDH1A1MEN1ADRA1D | |
| SCHEMBL19411000 | 0.70 | XIAP (0.49) | DRD2DRD4ROCK1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| CN-110753682-B | Substituted indoline derivatives as dengue virus replication inhibitors | 杨森制药公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20210300868-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2021-09-30 | — | — | US | disclosed |
| US-11053196-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | Janssen Pharmaceuticals, Inc. (US) | 2021-07-06 | — | — | US | disclosed |
| EP-3630724-B1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | JANSSEN PHARMACEUTICALS INC (US) | 2021-04-28 | — | — | EP | disclosed |
| US-20200181083-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | Janssen Pharmaceuticals, Inc. (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210300868-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | IDO1, INMT, IRF3 | DRD2 572/4885DRD4 217/4885ALDH1A1 3144/4885 |
| US-11053196-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | IDO1, INMT, IRF3 | DRD2 572/4885DRD4 217/4885ALDH1A1 3144/4885 |
| US-20200181083-A1 | SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS | IDO1, INMT, IRF3 | DRD2 572/4885DRD4 217/4885ALDH1A1 3144/4885 |
| US-11702387-B2 | Substituted indoline derivatives as dengue viral replication inhibitors | IDO1, INMT, IRF3 | DRD2 572/4885DRD4 217/4885ALDH1A1 3144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.