Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318630 | 0.89 | PDE7A (0.63) | PDE7AHTR2ASLC6A4MAOAMAOB | |
| SCHEMBL2509239 | 0.89 | PDE7A (0.56) | PDE7AFFAR1NPBWR1MCHR1HTR2A | |
| SCHEMBL22452604 | 0.85 | PDE7A (0.52) | PDE7AFFAR1NPBWR1MCHR1HTR2A | |
| SCHEMBL21925217 | 0.85 | MAPT (0.50) | PDE7ANPBWR1MCHR1MAOAMAOB | |
| SCHEMBL22966319 | 0.83 | ALDH1A1 (0.46) | PDE7AFFAR1NPBWR1MCHR1HTR2A | |
| SCHEMBL5583563 | 0.83 | TEAD4 (0.57) | PDE7AHTR2ASLC6A4MAOAMAOB | |
| SCHEMBL21620367 | 0.83 | FFAR1 (0.65) | FFAR1HTR2ASLC6A4ALDH1A1TDP1 | |
| SCHEMBL1147436 | 0.83 | PDE7A (0.53) | PDE7AHTR2ASLC6A4MAOAMAOB | |
| SCHEMBL8904604 | 0.82 | PDE7A (0.59) | PDE7AHTR2ASLC6A4MAOAMAOB | |
| SCHEMBL554722 | 0.82 | MAOA (0.61) | PDE7AFFAR1HTR2ASLC6A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |