Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | RNF4 | P78317 | 1/20 | 0.64 |
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22069671 | 0.92 | GAA (0.73) | KDM4ERECQLRNF4LTA4HGAA | |
| SCHEMBL23373325 | 0.88 | KDM4E (0.60) | KDM4ERECQLRNF4LTA4HGAA | |
| SCHEMBL23373333 | 0.87 | POLB (0.63) | KDM4ERECQLGAAMAPTALDH1A1 | |
| SCHEMBL23373386 | 0.87 | MTNR1B (0.73) | KDM4ERECQLGAAMTNR1AMTNR1B | |
| SCHEMBL23178156 | 0.86 | GAA (0.67) | KDM4ERECQLGAAMAPTALDH1A1 | |
| SCHEMBL5661261 | 0.85 | KDM4E (0.77) | KDM4ERECQLRNF4LTA4HGAA | |
| SCHEMBL5661438 | 0.85 | KDM4E (0.70) | KDM4ERECQLRNF4LTA4HGAA | |
| SCHEMBL22069565 | 0.84 | RECQL (0.75) | KDM4ERECQLRNF4LTA4HGAA | |
| SCHEMBL23373337 | 0.84 | GAA (0.64) | KDM4EGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5659423 | 0.83 | LTA4H (0.65) | KDM4ERECQLRNF4LTA4HGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |