Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25044550 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2CYP3A4CYP2C19LMNAPOLB | |
| SCHEMBL19465495 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAPOLBMEN1KMT2A | |
| SCHEMBL19853442 | 0.74 | TP53 (0.54) | SMN1; SMN2CYP2D6TSHRCYP2C19MEN1 | |
| SCHEMBL17666331 | 0.74 | SMN1; SMN2 (0.70) | SMN1; SMN2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL12121064 | 0.71 | HTT (0.63) | SMN1; SMN2CYP3A4TSHRCYP2C19MEN1 | |
| SCHEMBL3056874 | 0.71 | KMT2A (0.71) | SMN1; SMN2CYP2D6TSHRCYP2C19LMNA | |
| SCHEMBL20684992 | 0.70 | MEN1 (0.49) | SMN1; SMN2CYP3A4CYP2D6TSHRCYP2C19 | |
| SCHEMBL18415438 | 0.70 | LCK (0.57) | SMN1; SMN2CYP3A4LMNAMEN1KMT2A | |
| SCHEMBL1032002 | 0.69 | MAPK1 (0.77) | SMN1; SMN2CYP3A4CYP2C19LMNAMEN1 | |
| SCHEMBL13049648 | 0.69 | SMN1; SMN2 (1.00) | SMN1; SMN2POLBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11230535-B2 | CFTR regulators and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-01-25 | — | — | US | disclosed |
| US-20200181097-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230535-B2 | CFTR regulators and methods of use thereof | CFTR, SLC26A4, CLCN2 | SMN1; SMN2 4229/4885CYP3A4 1660/4885CYP2D6 2311/4885 |
| US-20200181097-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | CFTR, SLC26A4, CLCN2 | SMN1; SMN2 4229/4885CYP3A4 1660/4885CYP2D6 2311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.