Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22074786 | 0.83 | MAP3K12 (0.33) | MAP3K12ROCK1CDC42BPB | |
| SCHEMBL21658974 | 0.77 | MAP3K12 (0.40) | MAP3K12 | |
| SCHEMBL22074783 | 0.70 | ROCK1 (0.45) | ROCK1CDC42BPB | |
| SCHEMBL22074955 | 0.69 | ADORA3 (0.31) | — | |
| SCHEMBL21658975 | 0.60 | MAP3K12 (0.41) | MAP3K12 | |
| SCHEMBL26674815 | 0.59 | MAP4K4 (0.44) | — | |
| SCHEMBL31437287 | 0.59 | MAP4K4 (0.44) | — | |
| SCHEMBL16713266 | 0.59 | ADORA2B (0.37) | — | |
| SCHEMBL673109 | 0.58 | ROCK1 (0.40) | ROCK1CDC42BPB | |
| SCHEMBL2955534 | 0.55 | CCNT1 (0.43) | ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11129832-B2 | Biheteroaryl compounds and uses thereof | GENENTECH, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| US-20200188397-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11129832-B2 | Biheteroaryl compounds and uses thereof | BCHE, SNCA, HAX1 | MAP3K12 1980/4885ROCK1 778/4885CDC42BPB 2151/4885 |
| US-20200188397-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | BCHE, SNCA, HAX1 | MAP3K12 1980/4885ROCK1 778/4885CDC42BPB 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.