Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22079960 | 0.88 | TDP1 (0.40) | SMN1; SMN2TDP1LMNAPOLBALDH1A1 | |
| SCHEMBL22079982 | 0.79 | TDP1 (0.52) | HTTSMN1; SMN2TDP1LMNAALDH1A1 | |
| SCHEMBL24257942 | 0.79 | TDP1 (0.39) | SMN1; SMN2TDP1LMNAPOLBALDH1A1 | |
| SCHEMBL24257947 | 0.74 | TDP1 (0.35) | TDP1LMNAPOLBTP53 | |
| SCHEMBL24257929 | 0.73 | TDP1 (0.34) | TDP1LMNAPOLB | |
| SCHEMBL24257721 | 0.73 | TDP1 (0.34) | TDP1LMNAPOLBKDM4E | |
| SCHEMBL24257870 | 0.72 | TDP1 (0.33) | TDP1LMNAPOLB | |
| SCHEMBL24257838 | 0.71 | TDP1 (0.68) | HTTSMN1; SMN2TDP1LMNAALDH1A1 | |
| SCHEMBL24257917 | 0.71 | HDAC3 (0.39) | TDP1 | |
| SCHEMBL24257969 | 0.70 | TDP1 (0.44) | TDP1LMNAPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200181223-A1 | INSULIN CONJUGATES | SANOFI (FR) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181223-A1 | INSULIN CONJUGATES | IAPP, INSR, IGF1R | HTT 855/4885SMN1; SMN2 1332/4885TDP1 4783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.