Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.40 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11722438 | 0.79 | IDO1 (0.56) | MEN1KMT2ARAB9ACYP1A2CYP2C9 | |
| SCHEMBL6299575 | 0.76 | ALDH1A1 (0.42) | MEN1KMT2ARAB9ACYP1A2CYP2C9 | |
| SCHEMBL12164468 | 0.76 | ALDH1A1 (0.45) | MEN1KMT2ARAB9ACYP1A2CYP2C9 | |
| SCHEMBL5672563 | 0.74 | ALDH1A1 (0.41) | KMT2ARAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1149063 | 0.73 | MAPT (0.49) | MEN1KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL22648118 | 0.71 | ALDH1A1 (0.39) | MEN1KMT2ARAB9ACYP1A2CYP2C9 | |
| SCHEMBL15359017 | 0.71 | MAPK1 (0.42) | MEN1KMT2ARAB9ACYP1A2CYP2C9 | |
| SCHEMBL1539303 | 0.70 | SLC5A2 (0.50) | MEN1KMT2ARAB9ACYP1A2CYP2C9 | |
| SCHEMBL96393 | 0.70 | — | — | |
| SCHEMBL6282006 | 0.69 | SMN1; SMN2 (0.52) | MEN1KMT2ARAB9ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020117759-A1 | SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-06-11 | — | — | WO | disclosed |