Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22083949 | 0.80 | TAAR1 (0.35) | PKMCA1CA2CCNCCDK8 | |
| SCHEMBL22083883 | 0.72 | RORC (0.40) | CA1CA2CA12MEN1KMT2A | |
| SCHEMBL19941889 | 0.69 | POLB (0.52) | POLBPKMMAPTCCNCCDK8 | |
| SCHEMBL22084443 | 0.69 | BACE1 (0.40) | MAPTIDO1SMN1; SMN2TSHR | |
| SCHEMBL19941967 | 0.69 | MAPT (0.55) | POLBPKMMAPTCCNCCDK8 | |
| SCHEMBL19249326 | 0.67 | ERN1 (0.42) | POLBMAPTCA1CA2CA12 | |
| SCHEMBL27325893 | 0.66 | MAPT (0.61) | POLBPKMMAPTCCNCCDK8 | |
| SCHEMBL21518029 | 0.65 | TSHR (0.58) | CA1CA2CA12CA4IDO1 | |
| SCHEMBL9628053 | 0.65 | KCNH2 (0.73) | MAPTCA1CA2CA12CA4 | |
| SCHEMBL23073193 | 0.64 | MAPT (0.48) | POLBMAPTIDO1TDO2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020113816-A1 | 4-AROMATIC HETEROCYCLIC SUBSTITUTED INDAZOLE AND USE THEREOF AS IDO/TDO DUAL INHIBITOR | 西华大学 | 2020-06-11 | — | — | WO | disclosed |