Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8158910 | 0.82 | PARP1 (0.73) | PARP1 | |
| SCHEMBL4441357 | 0.82 | PARP1 (1.00) | PARP1 | |
| SCHEMBL2208978 | 0.82 | PARP1 (0.80) | PARP1 | |
| SCHEMBL3068304 | 0.81 | PARP1 (0.49) | PARP1 | |
| SCHEMBL30792539 | 0.81 | LMNA (0.59) | PARP1 | |
| SCHEMBL2473519 | 0.81 | LMNA (0.59) | PARP1 | |
| SCHEMBL30148159 | 0.81 | LMNA (0.59) | PARP1 | |
| SCHEMBL5126428 | 0.81 | PARP1 (1.00) | PARP1 | |
| SCHEMBL4433496 | 0.81 | PARP1 (1.00) | PARP1 | |
| SCHEMBL2763410 | 0.81 | PARP1 (0.69) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102952118-B | Poly-(ADP-ribose) AG14361, preparation method and its usage | SHANGHAI DE NOVO PHARMATECH CO LTD. (CN) | 2016-03-23 | — | — | CN | disclosed |
| CN-102952118-A | Poly(ADP-ribose)polymerase inhibitor, preparation method and application thereof | SHANGHAI DINUO MEDICAL TECHNOLOGY CO LTD | 2013-03-06 | — | — | CN | disclosed |
| US-7981890-B2 | Phthalazinone derivatives | ASTRAZENECA AB (SE) | 2011-07-19 | — | — | US | disclosed |
| US-7981890-B2 | Phthalazinone derivatives | ASTRAZENECA AB (SE) | 2011-07-19 | — | — | US | disclosed |
| US-7981890-B2 | Phthalazinone derivatives | ASTRAZENECA AB (SE) | 2011-07-19 | — | — | US | disclosed |
| EP-2188278-A1 | PHTHALAZINONE DERIVATIVES | AstraZeneca AB (SE) | 2010-05-26 | — | — | EP | disclosed |
| EP-2176237-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | AstraZeneca AB (SE) | 2010-04-21 | — | — | EP | disclosed |
| US-20090186897-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| US-20090186897-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| US-20090186897-A1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARMACEUTICALS LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| WO-2009034326-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034326-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| WO-2009004356-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |
| WO-2009004356-A1 | PHTHALAZINONE DERIVATIVES AS INHIBITORS OF PARP-1 | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023727-A1 | PHTHALAZINONE DERIVATIVES | NR0B2, NR0B1, NR2E1 | PARP1 3750/4885 |
| US-20090186897-A1 | PHTHALAZINONE DERIVATIVES | RCC2, CBR1, RCC1 | PARP1 1423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.