Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25297763 | 0.93 | CA2 (0.35) | MEN1KMT2AL3MBTL1NOTUMCA2 | |
| SCHEMBL25301900 | 0.89 | FFAR4 (0.39) | MEN1KMT2AL3MBTL1NOTUMCA2 | |
| SCHEMBL1727867 | 0.85 | MEN1 (0.41) | MEN1KMT2AL3MBTL1NOTUMCACNA1G | |
| SCHEMBL25250091 | 0.81 | NOTUM (0.38) | MEN1KMT2AL3MBTL1NOTUMCACNA1G | |
| SCHEMBL21503622 | 0.81 | SMN1; SMN2 (0.43) | MEN1KMT2AL3MBTL1NOTUMIDO1 | |
| SCHEMBL11502287 | 0.79 | RAB9A (0.50) | MEN1KMT2AL3MBTL1IDO1TDP1 | |
| SCHEMBL22071001 | 0.77 | CA2 (0.34) | CA2TDP1KDM4EALDH1A1ALOX5 | |
| SCHEMBL23062630 | 0.77 | NOTUM (0.40) | MEN1KMT2AL3MBTL1NOTUMCACNA1G | |
| SCHEMBL22719359 | 0.77 | NOTUM (0.40) | MEN1KMT2AL3MBTL1NOTUMCACNA1G | |
| SCHEMBL16843295 | 0.77 | NOTUM (0.40) | MEN1KMT2AL3MBTL1NOTUMCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894413-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123272-A1 | PYRAZOLOPYRIMIDINE PDE9 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2020-06-18 | — | — | WO | disclosed |