Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22092692 | 0.92 | POLB (0.44) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL24987471 | 0.89 | POLB (0.46) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL21887777 | 0.87 | MAPT (0.44) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL21887375 | 0.87 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL21887781 | 0.86 | NPSR1 (0.43) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL24985048 | 0.85 | NPC1 (0.37) | ALDH1A1NPC1RAB9ASMN1; SMN2ADORA2A | |
| SCHEMBL22092677 | 0.82 | TYK2 (0.44) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL21811192 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL22092671 | 0.81 | TYK2 (0.56) | POLBTYK2 | |
| SCHEMBL31245714 | 0.80 | TYK2 (0.54) | JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12060356-B2 | 7 (methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives | ELI LILLY AND COMPANY (US) | 2024-08-13 | — | — | US | disclosed |
| EP-3894412-B1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | LILLY CO ELI (US) | 2023-02-08 | — | — | EP | disclosed |
| US-20220024933-A1 | 7 (METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY | 2022-01-27 | — | — | US | disclosed |
| EP-3894412-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | Eli Lilly and Company (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123225-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2020123225-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2020-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12060356-B2 | 7 (methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives | SSB, TLR7, TPMT | KDM4E 802/4885ALDH1A1 1636/4885HPGD 3252/4885 |
| US-20220024933-A1 | 7 (METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | SSB, TLR7, TPMT | KDM4E 802/4885ALDH1A1 1636/4885HPGD 3252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.