Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22092692 | 0.93 | POLB (0.44) | POLBPDE2AALDH1A1KDM4EHPGD | |
| SCHEMBL22092637 | 0.89 | KDM4E (0.41) | POLBPDE2AALDH1A1KDM4EHPGD | |
| SCHEMBL24985048 | 0.86 | NPC1 (0.37) | POLBALDH1A1NPSR1TDP1L3MBTL1 | |
| SCHEMBL22092671 | 0.85 | TYK2 (0.56) | POLBTYK2STAT3 | |
| SCHEMBL21811164 | 0.78 | AKR1C3 (0.46) | POLBALDH1A1KDM4EHTTNPSR1 | |
| SCHEMBL21887372 | 0.78 | TDP1 (0.44) | POLBPDE2AALDH1A1KDM4EHTT | |
| SCHEMBL21887375 | 0.76 | KDM4E (0.42) | POLBPDE2AALDH1A1KDM4EHPGD | |
| SCHEMBL21887777 | 0.76 | MAPT (0.44) | POLBALDH1A1KDM4EHPGDHTT | |
| SCHEMBL22103738 | 0.76 | TYK2 (0.58) | TYK2STAT3 | |
| SCHEMBL21887378 | 0.75 | KCNH2 (0.44) | POLBALDH1A1KDM4EHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894412-B1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | LILLY CO ELI (US) | 2023-02-08 | — | — | EP | disclosed |