Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clomiphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 10/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | EBP | Q15125 | 5/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enclomiphene SCHEMBL8040981 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Zuclomiphene SCHEMBL223472 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Clomiphene SCHEMBL20942789 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Clomiphene SCHEMBL27599894 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Enclomiphene SCHEMBL220459 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8616232 | 0.94 | KMT2A (0.89) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8614802 | 0.94 | KMT2A (0.89) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8614814 | 0.94 | KMT2A (0.89) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8612826 | 0.93 | KMT2A (0.87) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8613135 | 0.93 | KMT2A (0.87) | KDM4EKMT2ACYP2D6MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5140 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146228-A1 | COMPOSITIONS AND METHODS FOR INDUCING OOCYTE MATURATION | GAMETO, INC. (US) | 2026-05-28 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-12569624-B2 | Devices, methods and compositions for reproductive organs | FEMASYS INC. (US) | 2026-03-10 | — | — | US | claimed |
| EP-4689070-A1 | METHODS AND COMPOSITIONS FOR PRODUCING OVARIAN SUPPORT CELL CO-CULTURE | Gameto, Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| US-12544387-B2 | Methods and compositions for testosterone production | SEPAH SAVIZ CAMERON (US) | 2026-02-10 | — | — | US | claimed |
| US-12533364-B2 | Methods and compositions for testosterone production | Saviz SEPAH (US) | 2026-01-27 | — | — | US | claimed |
| US-12533363-B2 | Methods and compositions for testosterone production | Sepah, Saviz (US) | 2026-01-27 | — | — | US | claimed |
| US-20260020843-A1 | TREATMENT OF MALE REPRODUCTIVE DISORDER | IMPERIAL COLLEGE INNOVATIONS LTD (GB) | 2026-01-22 | — | — | US | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20250368953-A1 | COMPOSITIONS AND METHODS FOR INDUCING OOCYTE MATURATION | GAMETO INC (US) | 2025-12-04 | — | — | US | claimed |
| EP-0305497-A4 | FERTILITY PREDICTION BY USE OF CLOMIPHENE CHALLENGE TEST. | NAVOT DANIEL | 1990-05-14 | — | — | EP | claimed |
| US-4894373-A | CLOMIPHEN, ISOMERS AND SALTS | BCM TECHNOLOGIES, INC. (US) | 1990-01-16 | — | — | US | claimed |
| EP-0305497-A1 | FERTILITY PREDICTION BY USE OF CLOMIPHENE CHALLENGE TEST. | NAVOT DANIEL | 1989-03-08 | — | — | EP | claimed |
| WO-1988006863-A1 | FERTILITY PREDICTION BY USE OF CLOMIPHENE CHALLENGE TEST | NAVOT DANIEL (US) | 1988-09-22 | — | — | WO | claimed |
| US-4729999-A | MENOPAUSE, SIDE EFFECT PREVENTION | BCM TECHNOLOGIES (US) | 1988-03-08 | — | — | US | claimed |
| EP-0178862-A2 | Antiestrogen therapy for symptoms of estrogen deficiency | BCM Technologies, INC. (US) | 1986-04-23 | — | — | EP | claimed |
| EP-0131166-A1 | Non-surgical apparatus for human embryo transfer | FERTILITY AND GENETICS RESEARCH, INC. (US) | 1985-01-16 | — | — | EP | claimed |
| EP-0059218-A4 | APPARATUS FOR ARTIFICIAL EMBRYONATION AND TISSUE RECOVERY. | SEED RICHARD G | 1983-10-06 | — | — | EP | claimed |
| EP-0059218-A1 | APPARATUS FOR ARTIFICIAL EMBRYONATION AND TISSUE RECOVERY. | SEED RICHARD G | 1982-09-08 | — | — | EP | claimed |
| WO-1982000754-A1 | METHODS AND APPARATUS FOR ARTIFICIAL EMBRYONATION AND TISSUE RECOVERY | SEED RICHARD G | 1982-03-18 | — | — | WO | claimed |