Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enclomiphene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 10/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | EBP | Q15125 | 5/20 | 0.75 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.75 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.75 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.75 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.75 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zuclomiphene SCHEMBL223472 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Clomiphene SCHEMBL220953 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Clomiphene SCHEMBL20942789 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Clomiphene SCHEMBL27599894 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Enclomiphene SCHEMBL220459 | 1.00 | KDM4E (1.00) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8616232 | 0.94 | KMT2A (0.89) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8614802 | 0.94 | KMT2A (0.89) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8614814 | 0.94 | KMT2A (0.89) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8612826 | 0.93 | KMT2A (0.87) | KDM4EKMT2ACYP2D6MEN1LMNA | |
| Citric Acid SCHEMBL8613135 | 0.93 | KMT2A (0.87) | KDM4EKMT2ACYP2D6MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000077590-A1 | APPARATUS FOR CALCULATING TIME PERIODS AND FUTURE DATES | CRAIG H RANDALL (US) | 2000-12-21 | — | — | WO | disclosed |