Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | NAPEPLD | Q6IQ20 | 4/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1751097 | 0.85 | KCNH2 (0.47) | ALDH1A1HSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL2202249 | 0.84 | ALDH1A1 (0.43) | ALDH1A1HSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL2206742 | 0.83 | ALDH1A1 (0.42) | ALDH1A1HSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL2208599 | 0.80 | JAK2 (0.49) | ALDH1A1HSP90AA1MAPTHTTSMN1; SMN2 | |
| SCHEMBL13672439 | 0.76 | ALDH1A1 (0.38) | ALDH1A1MAPTSMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL1379533 | 0.70 | KCNH2 (0.72) | ALDH1A1MAPTSMN1; SMN2CYP2C9KCNH2 | |
| SCHEMBL2205410 | 0.67 | CYP2C9 (0.77) | ALDH1A1MAPTSMN1; SMN2CYP2C9KCNH2 | |
| SCHEMBL12222752 | 0.67 | ALDH1A1 (0.39) | ALDH1A1MAPTSMN1; SMN2KDM4EMAPK1 | |
| Trifluoroacetic Acid SCHEMBL1751641 | 0.67 | KCNH2 (0.43) | RNASEH1CYP2C9KCNH2KDM4EERCC1 | |
| SCHEMBL2206374 | 0.66 | ALDH1A1 (0.40) | ALDH1A1HSP90AA1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257162-A1 | HIV INTEGRASE INHIBITORS | SUMMA VINCENZO | 2011-10-20 | — | — | US | disclosed |
| US-7981879-B2 | HIV integrase inhibitors | Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2011-07-19 | — | — | US | disclosed |
| US-20090253681-A1 | HIV Integrase Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257162-A1 | HIV INTEGRASE INHIBITORS | REV1, CDK9, INTS9 | ALDH1A1 4016/4885HSP90AA1 3958/4885MAPT 2670/4885 |
| US-20090253681-A1 | HIV Integrase Inhibitors | REV1, INTS9, H1-10 | ALDH1A1 4120/4885HSP90AA1 2992/4885MAPT 3157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.