Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 7/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 6/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27635233 | 0.77 | MAPK1 (0.43) | KLK7MAPK1BCHEKLK5PRSS1 | |
| SCHEMBL18593027 | 0.77 | MAPK1 (0.43) | KLK7MAPK1BCHEKLK5PRSS1 | |
| SCHEMBL20476783 | 0.74 | — | — | |
| SCHEMBL13409204 | 0.74 | USP2 (0.40) | KLK7MAPK1BCHEKDM4EMAPT | |
| SCHEMBL31750269 | 0.72 | KLK7 (0.36) | KLK7MAPK1BCHEKLK5PRSS1 | |
| SCHEMBL34473806 | 0.72 | KLK7 (0.36) | KLK7MAPK1BCHEKLK5PRSS1 | |
| SCHEMBL13391280 | 0.69 | USP2 (0.36) | KLK7BCHEKLK5PRSS1PRSS2 | |
| SCHEMBL8988562 | 0.69 | KLK7 (0.34) | KLK7MAPK1BCHEKLK5PRSS1 | |
| SCHEMBL483259 | 0.68 | CHRM2 (0.43) | KLK7MAPK1KDM4EMAPTTHRB | |
| SCHEMBL20406585 | 0.68 | CHRM2 (0.43) | KLK7MAPK1KDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3634409-B1 | OREXIN RECEPTOR ANTAGONISTS | BENEVOLENTAI BIO LTD (GB) | 2021-04-07 | — | — | EP | disclosed |
| US-20200190090-A1 | OREXIN RECEPTOR ANTAGONISTS | BENEVOLENTAI BIO LIMITED (GB) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190090-A1 | OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | KLK7 3268/4885MAPK1 1376/4885BCHE 2574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.