Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13360297 | 0.87 | POLB (0.57) | KMT2AMEN1ALOX12GAAPOLB | |
| SCHEMBL18159147 | 0.84 | ALOX12 (0.74) | KMT2AMEN1ALOX12GAAPOLB | |
| SCHEMBL8388698 | 0.81 | CA9 (0.55) | ALOX12GAAPOLBMAPTALDH1A1 | |
| SCHEMBL25184062 | 0.75 | ALOX12 (0.61) | KMT2AMEN1ALOX12GAAPOLB | |
| SCHEMBL12980282 | 0.73 | TRPV1 (0.60) | ALOX12MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1276262 | 0.73 | ALDH1A1 (0.56) | KMT2AMEN1ALOX12GAAMAPT | |
| SCHEMBL18771294 | 0.72 | HRH4 (0.53) | KMT2AMEN1GAAMAPTSMN1; SMN2 | |
| SCHEMBL11239091 | 0.72 | ALOX12 (0.86) | KMT2AMEN1ALOX12GAAPOLB | |
| SCHEMBL19234514 | 0.72 | KMT2A (0.61) | KMT2APOLBMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL26262850 | 0.72 | LPL (0.44) | KMT2AGAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019092618-A9 | GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF | IONIS PHARMACEUTICALS, INC (US) | 2020-06-18 | — | — | WO | disclosed |