Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20198075 | 0.92 | SMN1; SMN2 (0.39) | KMT2AMEN1LMNAHDAC2SMN1; SMN2 | |
| SCHEMBL19703232 | 0.88 | KMT2A (0.39) | KMT2AMEN1LMNAHDAC2SMN1; SMN2 | |
| SCHEMBL22147094 | 0.88 | KMT2A (0.41) | KMT2ALMNASMN1; SMN2RAB9APTGS1 | |
| SCHEMBL23867925 | 0.88 | FOLH1 (0.37) | KMT2AMEN1LMNASMN1; SMN2NPC1 | |
| SCHEMBL25681114 | 0.87 | KMT2A (0.40) | KMT2ASMN1; SMN2PTGS1PTGS2ALDH1A1 | |
| SCHEMBL19704786 | 0.87 | KMT2A (0.37) | KMT2AMEN1LMNAHDAC2SMN1; SMN2 | |
| SCHEMBL17722930 | 0.87 | KMT2A (0.37) | KMT2AMEN1LMNAHDAC2SMN1; SMN2 | |
| SCHEMBL17722936 | 0.87 | KMT2A (0.37) | KMT2AMEN1LMNAHDAC2SMN1; SMN2 | |
| SCHEMBL18264893 | 0.85 | OPRK1 (0.35) | KMT2AMEN1LMNASMN1; SMN2NPC1 | |
| SCHEMBL21516962 | 0.84 | KMT2A (0.39) | KMT2AMEN1LMNAHDAC2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3383909-B1 | ANTI-HUMAN LRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE | ABBVIE INC (US) | 2020-06-17 | — | — | EP | disclosed |