Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22100721 | 0.92 | KMT2A (0.40) | SMN1; SMN2NPC1RAB9AKMT2AHDAC2 | |
| SCHEMBL25681114 | 0.88 | KMT2A (0.40) | SMN1; SMN2KMT2APTGS1PTGS2TPSAB1 | |
| SCHEMBL22147094 | 0.87 | KMT2A (0.41) | SMN1; SMN2RAB9AKMT2ALMNAPTGS1 | |
| SCHEMBL25064904 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AKMT2AHDAC2 | |
| SCHEMBL20210383 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AKMT2AHDAC2 | |
| SCHEMBL23867925 | 0.87 | FOLH1 (0.37) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL19375644 | 0.85 | MMP3 (0.35) | SMN1; SMN2NPC1RAB9AKMT2AHDAC2 | |
| SCHEMBL22642708 | 0.84 | FAP (0.36) | SMN1; SMN2KMT2AHDAC2PTGS1PTGS2 | |
| SCHEMBL21416454 | 0.84 | FAP (0.36) | SMN1; SMN2KMT2AHDAC2PTGS1PTGS2 | |
| SCHEMBL16276530 | 0.82 | HRH1 (0.46) | SMN1; SMN2NPC1RAB9APRSS1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917195-B9 | SPLICEOSTATIN ANALOGS | PFIZER (US) | 2018-05-30 | — | — | EP | disclosed |