Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12424812 | 0.73 | ADORA2A (0.58) | ALDH1A1MEN1THRBKMT2A | |
| SCHEMBL2284708 | 0.72 | CCNB2 (0.61) | DAOATAD2CCNB2CDK1CCNB1 | |
| SCHEMBL1819378 | 0.72 | KMT2A (0.66) | NPC1ALDH1A1RAB9APKMMEN1 | |
| SCHEMBL25248466 | 0.70 | DAO (0.53) | DAOATAD2CCNB2CDK1CCNB1 | |
| SCHEMBL2118566 | 0.70 | DAO (0.53) | NR4A2DAOATAD2CDK1METAP2 | |
| SCHEMBL17686455 | 0.70 | KDM4C (0.60) | NR4A2GRM4DAOATAD2NPC1 | |
| SCHEMBL17686456 | 0.70 | KDM4C (0.60) | NR4A2DAOATAD2METAP2METAP1 | |
| SCHEMBL6489332 | 0.69 | CCNB2 (0.61) | DAOATAD2CCNB2CDK1CCNB1 | |
| SCHEMBL17686450 | 0.69 | KDM4C (0.61) | NR4A2GRM4ATAD2 | |
| SCHEMBL2289799 | 0.68 | DAO (0.47) | DAOATAD2CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123453-A2 | ALK5 INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2020-06-18 | — | — | WO | disclosed |