Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31143069 | 0.77 | DAO (0.65) | DAOATAD2MAPTHRH4NPC1 | |
| SCHEMBL24970980 | 0.77 | DAO (0.65) | DAOATAD2MAPTHRH4NPC1 | |
| SCHEMBL5790265 | 0.75 | DAO (0.53) | DAOATAD2NR4A2MAPTSNCA | |
| SCHEMBL4641753 | 0.75 | ATAD2 (0.62) | DAOATAD2MAPTSNCAHRH4 | |
| SCHEMBL29997480 | 0.75 | ATAD2 (0.62) | DAOATAD2MAPTSNCAHRH4 | |
| SCHEMBL25248466 | 0.75 | DAO (0.53) | DAOATAD2MAPTSNCAHRH4 | |
| SCHEMBL4420086 | 0.75 | DAO (0.53) | DAOATAD2MAPTSNCAHRH4 | |
| SCHEMBL12615150 | 0.75 | DAO (0.53) | DAOATAD2MAPTSNCAHRH4 | |
| SCHEMBL1472999 | 0.75 | DAO (0.62) | DAOATAD2MAPTSNCAHRH4 | |
| SCHEMBL4862801 | 0.75 | DAO (0.49) | DAOATAD2MAPTSNCAHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105732616-A | Pyrrolopyridine compounds containing biaryl amide structure, preparation method and applications thereof | 江西科技师范大学 | 2016-07-06 | — | — | CN | claimed |
| CN-102775404-B | Method for synthesizing 5-chloro-4-azaindole | CHEMFUTURE PHARMATECH JIANGSU LTD | 2015-06-03 | — | — | CN | claimed |
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |
| US-10385050-B2 | Indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives | HOFFMANN-LA ROCHE INC. (US) | 2019-08-20 | — | — | US | disclosed |
| CN-109952302-A | Muscarine M1 receptor forward direction allosteric modulators | 苏文生命科学有限公司 | 2019-06-28 | — | — | CN | disclosed |
| EP-3145923-B1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-01-30 | — | — | EP | disclosed |
| US-20190016719-A1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-10112938-B2 | Indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-10-30 | — | — | US | disclosed |
| CN-105732616-B | Pyrrolopyridines of the amide structure containing biaryl and its preparation method and application | 江西科技师范大学 | 2018-07-27 | — | — | CN | disclosed |
| EP-3145923-A1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2017-03-29 | — | — | EP | disclosed |
| US-20170057960-A1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-03-02 | — | — | US | disclosed |
| WO-2015177110-A1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |
| EP-2627655-B1 | FUSED 3-OXO-PYRAZOLO[4,3-c]PYRIDINE COMPOUNDS AS GABAA MODULATORS | DART NEUROSCIENCE CAYMAN LTD (KY) | 2015-09-16 | — | — | EP | disclosed |
| CN-102775404-B | Method for synthesizing 5-chloro-4-azaindole | CHEMFUTURE PHARMATECH JIANGSU LTD | 2015-06-03 | — | — | CN | disclosed |
| US-9012470-B2 | Therapeutic 5,6,5-tricyclic analogs | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2015-04-21 | — | — | US | disclosed |
| WO-2013150115-A1 | N- SUBSTITUTED HETERO - BICYCLIC COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2013-10-10 | — | — | WO | disclosed |
| WO-2013150115-A1 | N- SUBSTITUTED HETERO - BICYCLIC COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2013-10-10 | — | — | WO | disclosed |
| EP-2627655-A2 | THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS | Dart NeuroScience (Cayman) Ltd (KY) | 2013-08-21 | — | — | EP | disclosed |
| US-20120095016-A1 | THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS | HELICON THERAPEUTICS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2012051213-A2 | THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS | HELICON THERAPEUTICS, INC. (US) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385050-B2 | Indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives | TPH1, TPH2, HTR1A | DAO 1712/4885ATAD2 1348/4885NR4A2 669/4885 |
| US-20190016719-A1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES | TPH1, TPH2, HTR1A | DAO 1712/4885ATAD2 1348/4885NR4A2 669/4885 |
| US-20170057960-A1 | INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-c]PYRIDIN-2-ONE DERIVATIVES | TPH1, TPH2, HTR1A | DAO 1712/4885ATAD2 1348/4885NR4A2 669/4885 |
| US-10112938-B2 | Indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridin-2-one derivatives | TPH1, TPH2, HTR1A | DAO 1712/4885ATAD2 1348/4885NR4A2 669/4885 |
| US-20120095016-A1 | THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS | GABRA5, GABRA6, GABRB1 | DAO 1070/4885ATAD2 3756/4885NR4A2 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.