Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | TYK2 | P29597 | 10/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | INSRR | P14616 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21238680 | 0.74 | CDK7 (0.33) | CDK2CDK7CCNT1CDK1CDK4 | |
| SCHEMBL17980683 | 0.73 | GSK3B (0.47) | CDK2GSK3BTYK2CDK7PDE4D | |
| SCHEMBL18654699 | 0.73 | FLT3 (0.34) | CDK7CCNT1CDK9 | |
| SCHEMBL20689018 | 0.72 | KDM4E (0.52) | CDK2TYK2 | |
| SCHEMBL23772369 | 0.72 | CDK2 (0.46) | CDK2GSK3BTYK2CDK7PDE4D | |
| SCHEMBL20689133 | 0.71 | CDK2 (0.45) | CDK2GSK3BTYK2CDK7PDE4D | |
| SCHEMBL14543039 | 0.71 | GSK3B (0.61) | CDK2GSK3B | |
| SCHEMBL22342896 | 0.70 | KDM4E (0.50) | CDK2TYK2PDE4D | |
| SCHEMBL21947188 | 0.69 | TYK2 (0.61) | TYK2 | |
| SCHEMBL22342930 | 0.67 | TYK2 (0.39) | CDK2GSK3BTYK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894412-B1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | LILLY CO ELI (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2020123225-A1 | 7-(METHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2020-06-18 | — | — | WO | disclosed |