Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22324084 | 0.78 | TYK2 (0.61) | TYK2 | |
| SCHEMBL17980683 | 0.70 | GSK3B (0.47) | TYK2CDK2GSK3BCCNE1PDE2A | |
| SCHEMBL23772369 | 0.69 | CDK2 (0.46) | TYK2CDK2GSK3BCCNE1PDE2A | |
| SCHEMBL20689133 | 0.68 | CDK2 (0.45) | TYK2CDK2GSK3BCCNE1PDE2A | |
| SCHEMBL14543039 | 0.68 | GSK3B (0.61) | CDK2GSK3B | |
| SCHEMBL22342896 | 0.67 | KDM4E (0.50) | TYK2CDK2 | |
| SCHEMBL22103759 | 0.67 | CDK2 (0.40) | TYK2CDK2GSK3BCCNE1 | |
| SCHEMBL26253848 | 0.65 | PKM (0.42) | TYK2CDK2GSK3B | |
| SCHEMBL21947188 | 0.65 | TYK2 (0.61) | TYK2 | |
| SCHEMBL20689018 | 0.64 | KDM4E (0.52) | TYK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020163778-A1 | TYK2 PSEUDOKINASE LIGANDS | VENTYX BIOSCIENCES, INC. (US) | 2020-08-13 | — | — | WO | disclosed |