Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6764302 | 0.82 | HMGCR (0.35) | HMGCRHSP90AB1L3MBTL1 | |
| SCHEMBL6762080 | 0.81 | HMGCR (0.33) | HMGCR | |
| SCHEMBL6757347 | 0.69 | — | — | |
| SCHEMBL6762153 | 0.68 | — | — | |
| SCHEMBL6762156 | 0.68 | — | — | |
| SCHEMBL6760859 | 0.67 | — | — | |
| SCHEMBL23136619 | 0.62 | HMGCR (0.36) | HMGCR | |
| SCHEMBL614127 | 0.61 | PDE4A (0.31) | — | |
| SCHEMBL10261769 | 0.61 | SRC (0.39) | HSP90AB1L3MBTL1 | |
| SCHEMBL6762154 | 0.61 | NPSR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120136153-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-05-31 | — | — | US | disclosed |
| US-7982041-B2 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-07-19 | — | — | US | disclosed |
| US-20090198061-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-06 | — | — | US | disclosed |
| US-7538220-B2 | Intermediates in the preparation of homocamptothecin analogs | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-05-26 | — | — | US | disclosed |
| EP-1173180-B1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIV PITTSBURGH (US) | 2008-06-25 | — | — | EP | disclosed |
| US-20080027224-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-01-31 | — | — | US | disclosed |
| US-7220860-B2 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF PITTSBURGH (US) | 2007-05-22 | — | — | US | disclosed |
| US-20050014775-A1 | Camptothecin analogs and methods of preparation thereof | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2005-01-20 | — | — | US | disclosed |
| EP-1173180-A4 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIV PITTSBURGH (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6809103-B2 | E-RING EXPANDED CAMPTOTHECIN DERIVATIVES | UNIVERSITY OF PITTSBURGH | 2004-10-26 | — | — | US | disclosed |
| US-20030088101-A1 | E-ring expanded camptothecin derivatives | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2003-05-08 | — | — | US | disclosed |
| US-6410731-B2 | ENHANCED LIPOPHILICITY, BIOAVAILABILITY; MADE VIA A CASCADE RADICAL 4+1 ANNULATION INCLUDING REACTING A PRECURSOR WITH AN ARYLISONITRILE | UNIVERSITY OF PITTSBURGH | 2002-06-25 | — | — | US | disclosed |
| EP-1173180-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000061146-A9 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIV PITTSBURGH (US) | 2002-01-03 | — | — | WO | disclosed |
| US-20010003779-A1 | Camptothecin analogs and methods of preparation thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-06-14 | — | — | US | disclosed |
| US-6207832-B1 | ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH | 2001-03-27 | — | — | US | disclosed |
| WO-2000061146-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2000-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010003779-A1 | Camptothecin analogs and methods of preparation thereof | TOP1, CBR1, TOP2B | HMGCR 121/4885HSP90AB1 1359/4885L3MBTL1 2335/4885 |
| US-20030088101-A1 | E-ring expanded camptothecin derivatives | REL, TOP1, RRM1 | HMGCR 199/4885HSP90AB1 2668/4885L3MBTL1 1670/4885 |
| US-20090198061-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | TOP2A, TOP2B, ERCC4 | HMGCR 397/4885HSP90AB1 1437/4885L3MBTL1 4057/4885 |
| US-20050014775-A1 | Camptothecin analogs and methods of preparation thereof | NR0B1, NR5A1, REL | HMGCR 268/4885HSP90AB1 1795/4885L3MBTL1 2907/4885 |
| US-20120136153-A1 | CAMPTOTHECIN ANALOGS AND METHODS OF PREPARATION THEREOF | TOP2A, TOP2B, ERCC4 | HMGCR 397/4885HSP90AB1 1437/4885L3MBTL1 4057/4885 |
| US-20080027224-A1 | Camptothecin analogs and methods of preparation thereof | NR0B1, HCCS, NR0B2 | HMGCR 495/4885HSP90AB1 2179/4885L3MBTL1 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.