Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioglycolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioglycolic Acid SCHEMBL692043 | 1.00 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL10895895 | 0.92 | CA4 (0.53) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL16760982 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL1275216 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL216244 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL156458 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL59723 | 0.92 | — | — | |
| Thioglycolic Acid SCHEMBL8897741 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL4274828 | 0.92 | — | — | |
| Thioglycolic Acid SCHEMBL10795892 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981403-B2 | sulfur reducing agent with an oxidizing agent; thioglycolic acid, thiolactic acid, sodium bisulfite, calcium bisulfite, hydrogen peroxide | L'OREAL (FR) | 2011-07-19 | — | — | US | disclosed |