Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioglycolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioglycolic Acid SCHEMBL2211535 | 1.00 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL1275216 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL156458 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL10895895 | 0.92 | CA4 (0.53) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL8897741 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL4274828 | 0.92 | — | — | |
| Thioglycolic Acid SCHEMBL16760982 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL59723 | 0.92 | — | — | |
| Thioglycolic Acid SCHEMBL692043 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL10795892 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 581 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119050267-B | Positive electrode capable of limiting lattice oxygen escape and preparation method and application thereof | 华中科技大学 | 2026-05-12 | — | — | CN | claimed |
| CN-119430714-A | Application of waste water and waste residue of concrete mixing plant in concrete | 浙江交工集团股份有限公司 | 2025-02-14 | — | — | CN | claimed |
| US-20250032384-A1 | HAIR CARE COMPOSITION | CONOPCO, INC., D/B/A UNILEVER (US) | 2025-01-30 | — | — | US | claimed |
| CN-119050267-A | Positive electrode capable of limiting lattice oxygen escape and preparation method and application thereof | 华中科技大学 | 2024-11-29 | — | — | CN | claimed |
| EP-4440533-A1 | HAIR CARE COMPOSITION | Unilever IP Holdings B.V. (NL) | 2024-10-09 | — | — | EP | claimed |
| CN-118338882-A | Hair care compositions | 联合利华知识产权控股有限公司 | 2024-07-12 | — | — | CN | claimed |
| WO-2023094180-A1 | HAIR CARE COMPOSITION | UNILEVER IP HOLDINGS B.V. (NL) | 2023-06-01 | — | — | WO | claimed |
| CN-113208937-A | Cutin softening composition, preparation method and application thereof, external compound for treating onychomycosis, and preparation method and application thereof | 中国医学科学院北京协和医院 | 2021-08-06 | — | — | CN | claimed |
| US-20210015777-A1 | HEALING TOPICAL COMPOSITION | FLORENGALE, LLC | 2021-01-21 | — | — | US | claimed |
| US-10682324-B2 | Healing topical composition | FLORENGALE, LLC (US) | 2020-06-16 | — | — | US | claimed |
| US-20080210253-A1 | Hair care composition | PROCTER & GAMBLE COMPANY, THE | 2008-09-04 | — | — | US | claimed |
| US-20080187506-A1 | Hair care composition | PROCTER & GAMBLE COMPANY, THE | 2008-08-07 | — | — | US | claimed |
| WO-2008072122-A1 | WARMING PERSONAL CARE PRODUCTS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2008-06-19 | — | — | WO | claimed |
| US-20080145437-A1 | Reactive Chemistries For Warming Personal Care Products | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2008-06-19 | — | — | US | claimed |
| US-20060115445-A1 | Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents | L'OREAL S.A. (FR) | 2006-06-01 | — | — | US | claimed |
| US-20060083706-A1 | Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant | L'OREAL S.A. (FR) | 2006-04-20 | — | — | US | claimed |
| US-20060083762-A1 | Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles | L'OREAL S.A. (FR) | 2006-04-20 | — | — | US | claimed |
| US-20060078522-A1 | Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt | L'OREAL S.A. (FR) | 2006-04-13 | — | — | US | claimed |
| WO-2000057845-A1 | METHOD FOR REMOVAL OF HUMAN HORNY TISSUES | JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) | 2000-10-05 | — | — | WO | claimed |
| WO-1999049895-A2 | METHOD FOR INCREASING THE PERMEABILITY OF HORNY HUMAN TISSUE | JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) | 1999-10-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060083762-A1 | Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles | KRT18, PRKDC, ACP1 | CA4 3226/4885CASP1 3431/4885FFAR3 3962/4885 |
| US-20060115445-A1 | Compositions for treating keratin materials comprising electrophilic monomers and liquid crystal agents | KRT18, PRKDC, CUTA | CA4 2586/4885CASP1 2725/4885FFAR3 3092/4885 |
| US-20080210253-A1 | Hair care composition | MTR, SUCLG1, MUC1 | CA4 2879/4885CASP1 1054/4885FFAR3 3023/4885 |
| US-20250032384-A1 | HAIR CARE COMPOSITION | POLR1C, DPM1, NACA | CA4 1203/4885CASP1 3763/4885FFAR3 4301/4885 |
| US-20080187506-A1 | Hair care composition | MTR, SUCLG1, MUC1 | CA4 2879/4885CASP1 1054/4885FFAR3 3023/4885 |
| US-20060083706-A1 | Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant | MITF, CUTA, NACA | CA4 4628/4885CASP1 3357/4885FFAR3 2451/4885 |
| US-20210015777-A1 | HEALING TOPICAL COMPOSITION | CUTA, CSDE1, SRI | CA4 2478/4885CASP1 2633/4885FFAR3 4626/4885 |
| US-10682324-B2 | Healing topical composition | CUTA, CSDE1, SRI | CA4 2478/4885CASP1 2633/4885FFAR3 4626/4885 |
| US-20060078522-A1 | Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt | KRT18, DSG1, DSC1 | CA4 1016/4885CASP1 3790/4885FFAR3 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.