Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thioglycolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioglycolic Acid SCHEMBL2211463 | 1.00 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL10895895 | 0.92 | CA4 (0.53) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL16760982 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL1275216 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL216244 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL156458 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL59723 | 0.92 | — | — | |
| Thioglycolic Acid SCHEMBL8897741 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 | |
| Thioglycolic Acid SCHEMBL4274828 | 0.92 | — | — | |
| Thioglycolic Acid SCHEMBL10795892 | 0.92 | CA4 (0.47) | CA4CASP1FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 526 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119050267-B | Positive electrode capable of limiting lattice oxygen escape and preparation method and application thereof | 华中科技大学 | 2026-05-12 | — | — | CN | claimed |
| CN-119410039-A | Preparation method of multifunctional flame-retardant novel anti-skid pad | 浙江佳洁塑胶有限公司 | 2025-02-11 | — | — | CN | claimed |
| CN-119050267-A | Positive electrode capable of limiting lattice oxygen escape and preparation method and application thereof | 华中科技大学 | 2024-11-29 | — | — | CN | claimed |
| CN-118299598-A | S-Pt/N-NCP catalyst and preparation method thereof | 南京动量材料科技有限公司 | 2024-07-05 | — | — | CN | claimed |
| US-20240173451-A1 | FRAGRANCE COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME | Exuud, Inc. | 2024-05-30 | — | — | US | claimed |
| CN-117729945-A | Fragrance composition, method of making and articles comprising the same | 埃克苏德公司 | 2024-03-19 | — | — | CN | claimed |
| EP-4294465-A1 | FRAGRANCE COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME | Neerja Ventures, LLC (US) | 2023-12-27 | — | — | EP | claimed |
| WO-2022192215-A1 | FRAGRANCE COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME | NEERJA VENTURES, LLC (US) | 2022-09-15 | — | — | WO | claimed |
| CN-113208937-A | Cutin softening composition, preparation method and application thereof, external compound for treating onychomycosis, and preparation method and application thereof | 中国医学科学院北京协和医院 | 2021-08-06 | — | — | CN | claimed |
| US-20210015777-A1 | HEALING TOPICAL COMPOSITION | FLORENGALE, LLC | 2021-01-21 | — | — | US | claimed |
| EP-2442873-A2 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | Hds Limited (GB) | 2012-04-25 | — | — | EP | claimed |
| WO-2012025435-A2 | STABLE OXIDATIVE COLOURING COMPOSITION FOR KERATIN FIBRES | KPSS-KAO PROFESSIONAL SALON SERVICES GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2422762-A1 | Stable oxidative colouring composition for keratin fibers | KPSS-Kao Professional Salon Services GmbH (DE) | 2012-02-29 | — | — | EP | claimed |
| US-20110300083-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2011-12-08 | — | — | US | claimed |
| WO-2011143254-A2 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2011-11-17 | — | — | WO | claimed |
| WO-2010146142-A9 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LIMITED (GB) | 2011-06-16 | — | — | WO | claimed |
| WO-2010146142-A2 | METHODS AND COMPOUNDS FOR REDUCING ALLERGIC REACTIONS TO HAIR DYES | HDS LIMITED (GB) | 2010-12-23 | — | — | WO | claimed |
| US-20100189889-A1 | Method for Treating the Surface of a Substrate Based on Sulphur Polymer, Intended to be Covered with a Coating | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2010-07-29 | — | — | US | claimed |
| WO-2000057845-A1 | METHOD FOR REMOVAL OF HUMAN HORNY TISSUES | JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) | 2000-10-05 | — | — | WO | claimed |
| WO-1999049895-A2 | METHOD FOR INCREASING THE PERMEABILITY OF HORNY HUMAN TISSUE | JOHNSON AND JOHNSON CONSUMER COMPANIES, INC. (US) | 1999-10-07 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110300083-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | KAT7, CUTA, KAT6B | CA4 2810/4885CASP1 599/4885FFAR3 150/4885 |
| US-20210015777-A1 | HEALING TOPICAL COMPOSITION | CUTA, CSDE1, SRI | CA4 2478/4885CASP1 2633/4885FFAR3 4626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.