SCHEMBL22117376

SCHEMBL22117376

N=C(N)NCCC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)O)C(=O)N[C@@H](CC12CC3CC(CC(C3)C1)C2)C(=O)N[C@@H](CCCCNC(=O)OCc1ccccc1)C(N)=O

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CTSL P07711 1/20 0.49
▸ ERAP2 Q6P179 2/20 0.45
▸ ERAP1 Q9NZ08 2/20 0.45
▸ LNPEP Q9UIQ6 2/20 0.45
▸ NPY4R P50391 5/20 0.44
▸ PTGER4 P35408 4/20 0.44
▸ NPY1R P25929 3/20 0.44
▸ NPFFR1 Q9GZQ6 3/20 0.44
▸ NPFFR2 Q9Y5X5 3/20 0.44
▸ NPY2R P49146 2/20 0.44
▸ NPY5R Q15761 2/20 0.44
▸ OPRM1 P35372 2/20 0.43
▸ OPRD1 P41143 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22117377 1.00 CTSL (0.49) CTSLERAP2ERAP1LNPEPNPY4R
SCHEMBL22117808 0.97 CTSL (0.51) CTSLNPY4RPTGER4NPY1RNPY2R
SCHEMBL22117811 0.97 CTSL (0.51) CTSLNPY4RPTGER4NPY1RNPY2R
SCHEMBL22117557 0.97 CTSL (0.51) CTSLNPY4RPTGER4NPY1RNPY2R
SCHEMBL22117556 0.97 CTSL (0.51) CTSLNPY4RPTGER4NPY1RNPY2R
SCHEMBL25382492 0.92 ERAP2 (0.45) CTSLERAP2ERAP1LNPEPNPY4R
SCHEMBL25382487 0.92 ERAP2 (0.45) CTSLERAP2ERAP1LNPEPNPY4R
SCHEMBL31679039 0.92 KLK7 (0.49) CTSLNPY4RNPFFR1NPFFR2
SCHEMBL30341831 0.92 KLK7 (0.49) CTSLNPY4RNPFFR1NPFFR2
SCHEMBL28652171 0.91 CTSL (0.44) CTSLERAP2ERAP1LNPEPNPY4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230279052-A1 PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES STEALTH BIOTHERAPEUTICS INC. 2023-09-07 — — US disclosed
EP-3898652-A1 MITOCHONDRIA-TARGETING PEPTIDES Stealth Biotherapeutics Corp (MC) 2021-10-27 — — EP disclosed
WO-2020131282-A1 MITOCHONDRIA-TARGETING PEPTIDES STEALTH BIOTHERAPEUTICS CORP. (MC) 2020-06-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230279052-A1 PRODRUGS OF MITOCHONDRIA-TARGETING OLIGOPEPTIDES ARG2, NLN, OAT CTSL 273/4885ERAP2 184/4885ERAP1 188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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