Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12753749 | 0.81 | HSD11B1 (0.65) | TSHRMCOLN3MEN1KMT2AALDH1A1 | |
| SCHEMBL22120805 | 0.80 | TSHR (0.49) | TSHRCYP3A4CYP2C9CYP2C19MCOLN3 | |
| SCHEMBL9735682 | 0.80 | TSHR (0.49) | TSHRCYP3A4CYP2C9CYP2C19MCOLN3 | |
| SCHEMBL9734635 | 0.78 | SMN1; SMN2 (0.47) | TSHRCYP3A4CYP2C9CYP2C19MCOLN3 | |
| SCHEMBL22624291 | 0.75 | HSD11B1 (0.48) | MCOLN3LMNAHSD11B1 | |
| SCHEMBL9734149 | 0.74 | TSHR (0.42) | TSHRCYP3A4CYP2C9CYP2C19MCOLN3 | |
| SCHEMBL18918811 | 0.73 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL6616459 | 0.72 | TSHR (0.56) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL9734509 | 0.72 | HSD11B1 (0.42) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL4839 | 0.72 | HTR6 (0.48) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898592-A1 | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | Amgen Inc. (US) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020132653-A1 | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020132653-A1 | HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS | AMGEN INC. (US) | 2020-06-25 | — | — | WO | disclosed |