Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734509 | 0.99 | HSD11B1 (0.42) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL9735650 | 0.97 | HSD11B1 (0.43) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL9724526 | 0.86 | HSD11B1 (0.46) | TSHRMEN1KMT2AHSD11B1USP2 | |
| SCHEMBL9734258 | 0.86 | L3MBTL1 (0.43) | TSHRHSD11B1SMN1; SMN2LMNA | |
| SCHEMBL9734248 | 0.78 | CA1 (0.38) | HSD11B1HCAR1 | |
| SCHEMBL22120899 | 0.74 | TSHR (0.49) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL22120805 | 0.74 | TSHR (0.49) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL9735682 | 0.74 | TSHR (0.49) | TSHRCYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL9865854 | 0.74 | HCAR1 (0.39) | SMN1; SMN2HCAR1LMNA | |
| SCHEMBL9865677 | 0.73 | HCAR1 (0.36) | HCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5137886-A | Agriculture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-08-11 | — | — | US | claimed |
| US-5137886-A | Agriculture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-08-11 | — | — | US | disclosed |
| EP-0433001-A1 | Insecticidal compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-06-19 | — | — | EP | disclosed |