Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Uridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC28A1 | O00337 | 1/20 | 0.61 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.61 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.61 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | P2RY2 | P41231 | 9/20 | 0.46 |
| ▸ | P2RY6 | Q15077 | 8/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 7/20 | 0.45 |
| ▸ | P2RY4 | P51582 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uridine SCHEMBL3345043 | 0.91 | SLC28A1 (0.64) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Cytarabine SCHEMBL7053790 | 0.88 | LMNA (0.65) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Uridine SCHEMBL2028411 | 0.86 | SLC28A1 (0.65) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Uridine SCHEMBL2226523 | 0.85 | SLC28A1 (0.56) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Guanosine SCHEMBL8024691 | 0.84 | P2RY2 (0.56) | SLC28A1SLC28A2SLC29A1SLC28A3P2RY2 | |
| Uridine SCHEMBL3351395 | 0.83 | SLC28A1 (0.65) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Uridine SCHEMBL23243653 | 0.80 | SLC28A1 (0.64) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Ribavirin SCHEMBL13736866 | 0.80 | LMNA (0.64) | SLC28A1SLC28A2SLC29A1SLC28A3LMNA | |
| Thioguanine SCHEMBL16028922 | 0.80 | PNP (0.42) | LMNAMTOR | |
| Thioguanine SCHEMBL2936430 | 0.80 | PNP (0.42) | LMNAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020140730-A1 | USE OF THIOGUANINE IN PREPARATION OF DRUG FOR TREATING ADSL DEFICIENCY | 广州君赫生物科技有限公司 | 2020-07-09 | — | — | WO | disclosed |
| WO-2020125551-A1 | APPLICATION OF THIOGUANINE IN PREPARATION OF DRUGS FOR TREATMENT, IMPROVEMENT OR PREVENTION OF TUMORS | 广州君赫生物科技有限公司 | 2020-06-25 | — | — | WO | disclosed |