Uridine

Uridine

SCHEMBL2226523

Nc1nc2nc[nH]c2c(=O)[nH]1.Nc1ncnc2nc[nH]c12.O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.56
SLC28A2 O43868 1/20 0.56
SLC29A1 Q99808 1/20 0.56
SLC28A3 Q9HAS3 1/20 0.56
P2RY2 P41231 7/20 0.43
P2RY6 Q15077 6/20 0.43
P2RY14 Q15391 4/20 0.43
RNASEL Q05823 3/20 0.43
P2RY4 P51582 5/20 0.43
LMNA P02545 1/20 0.43
THRB P10828 1/20 0.43
MTOR P42345 1/20 0.43
MDM2 Q00987 1/20 0.43
NCOA1 Q15788 1/20 0.43
NCOA3 Q9Y6Q9 1/20 0.43
HIF1A Q16665 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Uridine SCHEMBL3345043 0.93 SLC28A1 (0.64) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Uridine SCHEMBL3351395 0.93 SLC28A1 (0.65) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Cytidine SCHEMBL16970937 0.89 LMNA (0.59) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Guanosine SCHEMBL8024691 0.86 P2RY2 (0.56) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Uridine SCHEMBL2028411 0.86 SLC28A1 (0.65) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Uridine SCHEMBL22129341 0.85 SLC28A1 (0.61) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Adenosine SCHEMBL8023430 0.85 ADORA3 (0.61) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Guanosine SCHEMBL439084 0.82 P2RY2 (0.52) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Cytidine SCHEMBL3129099 0.81 LMNA (0.67) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2
Guanosine SCHEMBL27658690 0.81 RNASEL (0.51) SLC28A1SLC28A2SLC29A1SLC28A3P2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9796996-B2 Means and methods for distinguishing FECV and FIPV UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2017-10-24 US disclosed
EP-2526209-B1 MEANS AND METHODS FOR DISTINGUISHING FECV AND FIPV UNIV UTRECHT HOLDING BV (NL) 2015-03-18 EP disclosed
US-20130071833-A1 MEANS AND METHODS FOR DISTINGUISHING FECV AND FIPV UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2013-03-21 US disclosed
WO-2011087366-A1 MEANS AND METHODS FOR DISTINGUISHING FECV AND FIPV UNIVERSITEIT UTRECHT HOLDING B.V. (NL) 2011-07-21 WO disclosed