Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RPA1 | P27694 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22147872 | 0.86 | TP53 (0.49) | MAPTNPC1TP53PKMNFKB1 | |
| SCHEMBL31066545 | 0.79 | NPC1 (0.41) | MAPTNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4913919 | 0.78 | TP53 (0.47) | MAPTNPC1TP53PKMNFKB1 | |
| SCHEMBL27038193 | 0.77 | NPC1 (0.36) | MAPTNPC1TP53PKMNFKB1 | |
| SCHEMBL4914133 | 0.76 | KMT2A (0.43) | NPC1TP53RAB9ARPA1KDM4E | |
| SCHEMBL3811214 | 0.76 | KDM4E (0.46) | MAPTNPC1RAB9ASMN1; SMN2RPA1 | |
| SCHEMBL3813756 | 0.76 | RPA1 (0.45) | MAPTTP53SMN1; SMN2RPA1KDM4E | |
| SCHEMBL28521561 | 0.74 | RPA1 (0.40) | MAPTRPA1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL31052618 | 0.73 | LMNA (0.39) | MAPTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL6821430 | 0.73 | PDE10A (0.46) | MAPTNPC1TP53RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111349093-B | 5, 6-bicyclic compounds as WNT signal pathway inhibitors and medical application thereof | 汇瀚医疗科技有限公司 | 2021-07-02 | — | — | CN | disclosed |
| CN-111349093-A | 5, 6-bicyclic compounds as WNT signal pathway inhibitors and medical application thereof | 汇瀚医疗科技有限公司 | 2020-06-30 | — | — | CN | disclosed |
| WO-2020125759-A1 | COMPOUND AS WNT SIGNAL PATHWAY INHIBITOR AND MEDICAL USE THEREOF | 汇瀚医疗科技有限公司 | 2020-06-25 | — | — | WO | disclosed |
| WO-2020125759-A1 | COMPOUND AS WNT SIGNAL PATHWAY INHIBITOR AND MEDICAL USE THEREOF | 汇瀚医疗科技有限公司 | 2020-06-25 | — | — | WO | disclosed |