Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | MARS1 | P56192 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818150 | 0.81 | NR1H4 (0.39) | RPA1SMN1; SMN2L3MBTL1PPP1CA | |
| SCHEMBL30971768 | 0.81 | TP53 (0.45) | SMN1; SMN2KDM4EKMT2ATP53MAPT | |
| SCHEMBL3812681 | 0.81 | RAB9A (0.55) | SMN1; SMN2KDM4EKMT2ATP53MAPT | |
| SCHEMBL4914133 | 0.79 | KMT2A (0.43) | RPA1PPP1CAKDM4EMEN1KMT2A | |
| SCHEMBL3811214 | 0.79 | KDM4E (0.46) | RPA1SMN1; SMN2KDM4EMAPTAPOBEC3A | |
| SCHEMBL31066545 | 0.79 | NPC1 (0.41) | RPA1SMN1; SMN2PPP1CAKDM4EMEN1 | |
| SCHEMBL3816104 | 0.76 | KDM4E (0.70) | KDM4ETP53MAPT | |
| SCHEMBL22129472 | 0.76 | MAPT (0.47) | RPA1SMN1; SMN2L3MBTL1KDM4EATM | |
| SCHEMBL17252261 | 0.76 | MARS1 (0.41) | KDM4EMEN1KMT2ATP53APOBEC3A | |
| SCHEMBL3817393 | 0.74 | KDM4E (0.71) | SMN1; SMN2KDM4ETP53MAPTAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| US-20250074922-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. | 2025-03-06 | — | — | US | disclosed |
| US-11919915-B2 | Compounds and methods useful for stabilizing phenylalanine hydroxylase mutations | AGIOS PHARMACEUTICALS, INC. (US) | 2024-03-05 | — | — | US | disclosed |
| US-20230365592-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. | 2023-11-16 | — | — | US | disclosed |
| US-20230339980-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-10-26 | — | — | US | disclosed |
| WO-2023164235-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| US-10759815-B2 | Condensed heterocyclic compounds and pesticides | NISSAN CHEMICAL CORPORATION (JP) | 2020-09-01 | — | — | US | disclosed |
| US-20200223868-A1 | CONDENSED HETEROCLYCLIC COMPOUNDS AND PESTICIDES | NISSAN CHEMICAL CORPORATION (JP) | 2020-07-16 | — | — | US | disclosed |
| US-10640518-B2 | Condensed heterocyclic compounds and pesticides | NISSAN CHEMICAL CORPORATION (JP) | 2020-05-05 | — | — | US | disclosed |
| US-20200095263-A1 | CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES | NISSAN CHEMICAL CORPORATION (JP) | 2020-03-26 | — | — | US | disclosed |
| US-10544163-B2 | Condensed heterocyclic compounds and pesticides | NISSAN CHEMICAL CORPORATION (JP) | 2020-01-28 | — | — | US | disclosed |
| EP-3428166-A1 | CONDENSED HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT | Nissan Chemical Corporation (JP) | 2019-01-16 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |
| EP-1778685-B1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SANOL ARZNEI SCHWARZ GMBH (DE) | 2008-03-26 | — | — | EP | disclosed |
| US-20080051409-A1 | Indolizine Carboxamides and Aza and Diaza Derivatives Thereof | SCHWARZ PHARMA AG (DE) | 2008-02-28 | — | — | US | disclosed |
| EP-1778685-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006015737-A1 | INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF | SCHWARZ PHARMA AG (DE) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11919915-B2 | Compounds and methods useful for stabilizing phenylalanine hydroxylase mutations | PAH, KDM8, PHF8 | RPA1 1104/4885SMN1; SMN2 1592/4885L3MBTL1 68/4885 |
| US-20080051409-A1 | Indolizine Carboxamides and Aza and Diaza Derivatives Thereof | GRIN2A, GRIN2C, GRIN1 | RPA1 4463/4885SMN1; SMN2 3676/4885L3MBTL1 4871/4885 |
| US-10759815-B2 | Condensed heterocyclic compounds and pesticides | NR4A1, CHRM1, NR1D2 | RPA1 3703/4885SMN1; SMN2 3946/4885L3MBTL1 1715/4885 |
| US-20230365592-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | RPA1 1104/4885SMN1; SMN2 1592/4885L3MBTL1 68/4885 |
| US-20250074922-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | RPA1 577/4885SMN1; SMN2 1455/4885L3MBTL1 556/4885 |
| US-20200223868-A1 | CONDENSED HETEROCLYCLIC COMPOUNDS AND PESTICIDES | CHRM1, HCRTR1, NR4A1 | RPA1 4048/4885SMN1; SMN2 4303/4885L3MBTL1 1847/4885 |
| US-10544163-B2 | Condensed heterocyclic compounds and pesticides | NR4A1, CHRM1, NR1D2 | RPA1 3652/4885SMN1; SMN2 3930/4885L3MBTL1 1759/4885 |
| US-20230339980-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | RPA1 1104/4885SMN1; SMN2 1592/4885L3MBTL1 68/4885 |
| US-20200095263-A1 | CONDENSED HETEROCYCLIC COMPOUNDS AND PESTICIDES | NR4A1, CHRM1, NR1D2 | RPA1 3652/4885SMN1; SMN2 3930/4885L3MBTL1 1759/4885 |
| US-10640518-B2 | Condensed heterocyclic compounds and pesticides | NR4A1, CHRM1, NR1D2 | RPA1 3745/4885SMN1; SMN2 3966/4885L3MBTL1 1748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.