SCHEMBL2213033

SCHEMBL2213033

CN(C)CC/C=C1/c2ccccc2COc2ccc(O)cc21

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 4/20 0.75
KCNH2 Q12809 2/20 0.75
HTR2B P41595 2/20 0.75
ALDH1A1 P00352 2/20 0.75
LMNA P02545 2/20 0.75
SLC22A1 O15245 1/20 0.75
CHRM2 P08172 1/20 0.75
CHRM4 P08173 1/20 0.75
HTR1A P08908 1/20 0.75
CHRM5 P08912 1/20 0.75
ADRA2A P08913 1/20 0.75
CHRM1 P11229 1/20 0.75
DRD2 P14416 1/20 0.75
ADRA2B P18089 1/20 0.75
ADRA2C P18825 1/20 0.75
CHRM3 P20309 1/20 0.75
DRD1 P21728 1/20 0.75
DRD4 P21917 1/20 0.75
DRD5 P21918 1/20 0.75
SLC6A2 P23975 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1695226 1.00 HRH1 (0.75) HRH1KCNH2HTR2BALDH1A1LMNA
SCHEMBL2213039 1.00 HRH1 (0.75) HRH1KCNH2HTR2BALDH1A1LMNA
SCHEMBL2738871 0.92 HTR2B (0.77) HRH1KCNH2HTR2BALDH1A1LMNA
SCHEMBL10345076 0.88 HTR2B (0.81) HRH1KCNH2HTR2BALDH1A1LMNA
SCHEMBL10344955 0.88 HTR2B (0.81) HRH1KCNH2HTR2BALDH1A1LMNA
SCHEMBL10344954 0.88 HTR2B (0.81) HRH1KCNH2HTR2BALDH1A1LMNA
Hydrochloric Acid SCHEMBL9133126 0.87 HTR2B (0.79) HRH1KCNH2HTR2BALDH1A1LMNA
Hydrochloric Acid SCHEMBL9133130 0.87 HTR2B (0.79) HRH1KCNH2HTR2BALDH1A1LMNA
SCHEMBL2615216 0.87 HRH1 (0.77) HRH1KCNH2HTR2BALDH1A1LMNA
Doxepin SCHEMBL28075931 0.86 HTR2B (0.95) HRH1KCNH2HTR2BALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250268858-A1 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep CURRAX PHARMACEUTICALS LLC (US) 2025-08-28 US disclosed
US-12083090-B2 Methods of using low-dose doxepin for the improvement of sleep CURRAX PHARMACEUTICALS LLC (US) 2024-09-10 US disclosed
US-11007168-B2 Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders CURRAX PHARMACEUTICALS LLC (US) 2021-05-18 US disclosed
US-20200345680-A1 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep CURRAX PHARMACEUTICALS LLC (US) 2020-11-05 US disclosed
US-10758510-B2 Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders CURRAX PHARMACEUTICALS LLC (US) 2020-09-01 US disclosed
US-10653662-B2 Methods of using low-dose doxepin for the improvement of sleep CURRAX PHARMACEUTICALS LLC (US) 2020-05-19 US disclosed
US-20200101037-A1 Doxepin Trans Isomers And Isomeric Mixtures And Methods Of Using The Same To Treat Sleep Disorders WILMINGTON SAVINGS FUND SOCIETY, FSB 2020-04-02 US disclosed
US-20190216766-A1 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep WILMINGTON SAVINGS FUND SOCIETY, FSB 2019-07-18 US disclosed
US-20190099396-A1 Doxepin Trans Isomers And Isomeric Mixtures And Methods Of Using The Same To Treat Sleep Disorders WILMINGTON SAVINGS FUND SOCIETY, FSB 2019-04-04 US disclosed
US-10238620-B2 Methods of using low-dose doxepin for the improvement of sleep PERNIX SLEEP, INC. (US) 2019-03-26 US disclosed
US-8513299-B2 Sleep efficiency PERNIX SLEEP, INC. (US) 2013-08-20 US disclosed
US-20130102658-A1 DOXEPIN ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS PROCOM ONE, INC. (US) 2013-04-25 US disclosed
US-20130096188-A1 DOXEPIN TRANS ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS PROCOM ONE, INC. (US) 2013-04-18 US disclosed
US-20120245222-A1 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP SOMAXON PHARMACEUTICALS, INC. (US) 2012-09-27 US disclosed
US-20110178166-A1 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP SOMAXON PHARMACEUTICALS, INC. (US) 2011-07-21 US disclosed
US-20100179215-A1 DOXEPIN ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS SOMAXON PHARMACEUTICALS, INC. (US) 2010-07-15 US disclosed
US-20100179214-A1 DOXEPIN TRANS ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS SOMAXON PHARMACEUTICALS, INC. (US) 2010-07-15 US disclosed
US-20090042971-A1 METHOD OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP SOMAXON PHARMACEUTICALS, INC. (US) 2009-02-12 US disclosed
US-20090042972-A1 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP SOMAXON PHARMACEUTICALS, INC. (US) 2009-02-12 US disclosed
US-20070281990-A1 Methods of using low-dose doxepin for the improvement of sleep WILMINGTON SAVINGS FUND SOCIETY, FSB 2007-12-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (19 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100179215-A1 DOXEPIN ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS CYP3A5, CYP2D6, CYP2C18 HRH1 296/4885KCNH2 3264/4885HTR2B 251/4885
US-20200101037-A1 Doxepin Trans Isomers And Isomeric Mixtures And Methods Of Using The Same To Treat Sleep Disorders CYP3A5, CYP21A2, CYP2D6 HRH1 299/4885KCNH2 3272/4885HTR2B 270/4885
US-20100179214-A1 DOXEPIN TRANS ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS CYP3A5, CYP21A2, CYP2D6 HRH1 299/4885KCNH2 3272/4885HTR2B 270/4885
US-20090042971-A1 METHOD OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP BCHE, PER2, DPEP1 HRH1 532/4885KCNH2 1963/4885HTR2B 697/4885
US-20130102658-A1 DOXEPIN ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS CYP3A5, CYP2D6, CYP2C18 HRH1 296/4885KCNH2 3264/4885HTR2B 251/4885
US-12083090-B2 Methods of using low-dose doxepin for the improvement of sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-11007168-B2 Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders CYP3A5, CYP2D6, CYP21A2 HRH1 328/4885KCNH2 3325/4885HTR2B 300/4885
US-20130096188-A1 DOXEPIN TRANS ISOMERS AND ISOMERIC MIXTURES AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS CYP3A5, CYP21A2, CYP2D6 HRH1 299/4885KCNH2 3272/4885HTR2B 270/4885
US-20090042972-A1 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-20190216766-A1 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-10758510-B2 Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders CYP3A5, CYP2D6, CYP2C18 HRH1 296/4885KCNH2 3264/4885HTR2B 251/4885
US-20250268858-A1 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-10238620-B2 Methods of using low-dose doxepin for the improvement of sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-10653662-B2 Methods of using low-dose doxepin for the improvement of sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-20190099396-A1 Doxepin Trans Isomers And Isomeric Mixtures And Methods Of Using The Same To Treat Sleep Disorders CYP3A5, CYP21A2, CYP2D6 HRH1 299/4885KCNH2 3272/4885HTR2B 270/4885
US-20120245222-A1 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-20110178166-A1 METHODS OF USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-20200345680-A1 Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885
US-20070281990-A1 Methods of using low-dose doxepin for the improvement of sleep PER2, BCHE, MTNR1A HRH1 436/4885KCNH2 2152/4885HTR2B 558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.