SCHEMBL22136018

SCHEMBL22136018

Nc1ncc2ccc3ccccc3c2n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CLK1 P49759 2/20 0.62
DYRK1A Q13627 1/20 0.62
F12 P00748 1/20 0.44
PLAU P00749 1/20 0.44
NCF1 P14598 1/20 0.44
NOS3 P29474 1/20 0.44
NOS1 P29475 1/20 0.44
NOS2 P35228 1/20 0.44
BACE1 P56817 1/20 0.44
PRMT5 O14744 1/20 0.44
PRMT3 O60678 1/20 0.44
CARM1 Q86X55 1/20 0.44
EHMT2 Q96KQ7 1/20 0.44
PRMT6 Q96LA8 1/20 0.44
PRMT1 Q99873 1/20 0.44
WDR77 Q9BQA1 1/20 0.44
ALDH1A1 P00352 2/20 0.42
TSHR P16473 2/20 0.42
HSD17B10 Q99714 2/20 0.42
CYP2A6 P11509 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13591668 0.78 LMNA (0.58) CLK1DYRK1ANCF1ALDH1A1TSHR
SCHEMBL17532736 0.76 CYP2A6 (0.44) ALDH1A1TSHRHSD17B10CYP2A6TDP1
SCHEMBL28416889 0.76 NPC1 (0.46) CLK1DYRK1AALDH1A1TSHRHSD17B10
SCHEMBL22349597 0.76 ALDH1A1 (0.42) CLK1DYRK1AF12PLAUNCF1
SCHEMBL30783275 0.76 ALDH1A1 (0.42) CLK1DYRK1AF12PLAUNCF1
SCHEMBL18017046 0.76 MAPT (0.44) CLK1DYRK1AF12PLAUNCF1
SCHEMBL19318052 0.76 ALDH1A1 (0.42) CLK1DYRK1AF12PLAUNCF1
SCHEMBL30968858 0.76 CLK1 (0.57) CLK1DYRK1ABACE1ALDH1A1HSD17B10
SCHEMBL30968859 0.76 CLK1 (0.57) CLK1DYRK1ABACE1ALDH1A1HSD17B10
SCHEMBL29286158 0.76 CLK1 (0.57) CLK1DYRK1ABACE1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020130553-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME 두산솔루스 주식회사 2020-06-25 WO disclosed
CN-107892654-B Isolongifolane-based fluorescent acid-base indicator and synthetic method and application thereof 南京林业大学 2020-02-14 CN disclosed