Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 16/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22136291 | 0.85 | STING1 (0.55) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22136264 | 0.80 | STING1 (0.60) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22135959 | 0.79 | MAP3K7 (0.46) | STING1TBK1MAP3K7KMT2A | |
| SCHEMBL22136293 | 0.74 | CXCR4 (0.53) | STING1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22135277 | 0.73 | STING1 (0.55) | STING1TBK1KMT2A | |
| SCHEMBL22135276 | 0.73 | STING1 (0.81) | STING1TBK1 | |
| SCHEMBL22136253 | 0.71 | STING1 (0.50) | STING1TBK1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL22135898 | 0.71 | STING1 (0.54) | STING1 | |
| SCHEMBL22135915 | 0.69 | STING1 (0.62) | STING1TBK1MAP3K7KMT2A | |
| SCHEMBL22134963 | 0.67 | HPGD (0.62) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132549-A1 | STING HETEROCYCLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |