Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 11/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.42 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22136298 | 0.90 | RAB9A (0.45) | STING1RAB9ANPC1SMN1; SMN2CYP2C19 | |
| SCHEMBL22135908 | 0.85 | STING1 (0.56) | STING1TBK1MAP3K7RAB9ANPC1 | |
| SCHEMBL22136264 | 0.82 | STING1 (0.60) | STING1TBK1MAP3K7CYP2C19MEN1 | |
| SCHEMBL22136125 | 0.80 | STING1 (0.47) | STING1TBK1CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL22136291 | 0.80 | STING1 (0.55) | STING1TBK1MAP3K7CYP2C19MEN1 | |
| SCHEMBL22150261 | 0.79 | STING1 (0.67) | STING1TBK1 | |
| SCHEMBL22135941 | 0.78 | MAP3K7 (0.53) | STING1TBK1MAP3K7RAB9ANPC1 | |
| SCHEMBL22136283 | 0.78 | KDM4E (0.59) | MAP3K7RAB9ANPC1SMN1; SMN2CYP2C19 | |
| SCHEMBL22150251 | 0.76 | STING1 (0.43) | STING1TBK1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL22136293 | 0.74 | CXCR4 (0.53) | STING1KMT2AJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132549-A1 | STING HETEROCYCLE AGONISTS AND USES THEREOF | NIMBUS TITAN, INC. (US) | 2020-06-25 | — | — | WO | disclosed |