Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 5/20 | 0.67 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.67 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.67 |
| ▸ | LTA4H | P09960 | 12/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25059499 | 0.98 | PSMB1 (0.70) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL25059429 | 0.96 | PSMB1 (0.62) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL3578646 | 0.83 | HRH3 (0.90) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL4517043 | 0.81 | PSMB1 (0.67) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL5606946 | 0.81 | PSMB1 (0.67) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL8337754 | 0.81 | HRH3 (0.70) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL1986761 | 0.81 | PSMB1 (0.67) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL13896856 | 0.81 | PSMB1 (0.67) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL3578343 | 0.81 | PSMB1 (0.67) | PSMB1PSMB5PSMB2LTA4HHRH3 | |
| SCHEMBL7819691 | 0.81 | LTA4H (0.90) | PSMB1PSMB5PSMB2LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765789-B2 | 2-pyridinecarboxamide derivatives | MSD K.K. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20130085156-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2013-04-04 | — | — | US | disclosed |
| US-8344003-B2 | 2-pyridinecarboxamide derivatives | MSD K. K. (JP) | 2013-01-01 | — | — | US | disclosed |
| EP-1598349-B1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD KK (JP) | 2011-07-27 | — | — | EP | disclosed |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2010-02-18 | — | — | US | disclosed |
| US-7629362-B2 | 2-pyridine carboxamide derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-12-08 | — | — | US | disclosed |
| US-20060258701-A1 | Novel 2-pyridinecarboxamide derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-16 | — | — | US | disclosed |
| EP-1598349-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130085156-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | PSMB1 3765/4885PSMB5 2203/4885PSMB2 3252/4885 |
| US-20060258701-A1 | Novel 2-pyridinecarboxamide derivatives | GCKR, GCK, HK2 | PSMB1 3791/4885PSMB5 2223/4885PSMB2 3319/4885 |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | PSMB1 3765/4885PSMB5 2203/4885PSMB2 3252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.