Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | PLAT | P00750 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.36 |
| ▸ | ITGA2 | P17301 | 4/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215284 | 0.83 | F2 (0.39) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2213649 | 0.83 | NAMPT (0.39) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2211714 | 0.81 | MELK (0.46) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2213856 | 0.80 | MELK (0.48) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2882257 | 0.80 | CHEK2 (0.48) | KLKB1GSK3BRAB9ACASP3SENP7 | |
| SCHEMBL2213794 | 0.80 | ROCK2 (0.40) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2214210 | 0.79 | WNT1 (0.42) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2214775 | 0.79 | PLAU (0.49) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2215892 | 0.78 | PLG (0.45) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2215043 | 0.78 | F2 (0.39) | F2PLGPLAUPLATKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |