Sugi Predict

Sugi Predict / Compounds / SCHEMBL221449

SCHEMBL221449

SCHEMBL221449

O=C(O)c1cc(F)c(Cl)cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.53
▸ NFE2L2 Q16236 1/20 0.53
▸ CA12 O43570 1/20 0.50
▸ CA1 P00915 1/20 0.50
▸ CA2 P00918 1/20 0.50
▸ CA3 P07451 1/20 0.50
▸ CA4 P22748 1/20 0.50
▸ CA6 P23280 1/20 0.50
▸ CA5A P35218 1/20 0.50
▸ CA7 P43166 1/20 0.50
▸ CA9 Q16790 1/20 0.50
▸ CA13 Q8N1Q1 1/20 0.50
▸ CISD1 Q9NZ45 1/20 0.50
▸ CA14 Q9ULX7 1/20 0.50
▸ CA5B Q9Y2D0 1/20 0.50
▸ ALDH1A1 P00352 3/20 0.48
▸ TSHR P16473 2/20 0.48
▸ TP53 P04637 1/20 0.48
▸ CASP1 P29466 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Potassium SCHEMBL30811379 0.98 KEAP1 (0.52) KEAP1NFE2L2CA12CA1CA2
Hydrochloric Acid SCHEMBL11043790 0.98 KEAP1 (0.52) KEAP1NFE2L2CA12CA1CA2
SCHEMBL29181699 0.98 KEAP1 (0.52) KEAP1NFE2L2CA12CA1CA2
SCHEMBL28026061 0.98 KEAP1 (0.52) KEAP1NFE2L2CA12CA1CA2
SCHEMBL364382 0.91 KEAP1 (0.48) KEAP1NFE2L2CA12CA1CA2
SCHEMBL31586627 0.88 KEAP1 (0.55) KEAP1NFE2L2ALDH1A1TSHRTP53
SCHEMBL979056 0.88 KEAP1 (0.55) KEAP1NFE2L2CA12CA1CA2
SCHEMBL32668944 0.88 KEAP1 (0.55) KEAP1NFE2L2CA12CA1CA2
SCHEMBL223134 0.86 KEAP1 (0.53) KEAP1NFE2L2ALDH1A1TSHRTP53
Hydrochloric Acid SCHEMBL9488278 0.86 KEAP1 (0.53) KEAP1NFE2L2CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 230 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP claimed
CN-117402055-B Resource utilization method of 2, 4-dichloro-5-fluoroacetophenone mother liquor 浙江吉泰新材料股份有限公司 2024-10-29 — — CN claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO claimed
CN-117736083-A Method for preparing 2, 4-dichloro-5-fluorobenzoic acid and 2, 6-dichloro-3-fluorobenzoic acid by taking 2, 4-dichloro-5-fluoroacetophenone crystallization mother liquor as raw material 浙江工业大学 2024-03-22 — — CN claimed
CN-117486674-A Comprehensive utilization method of 2, 4-dichloro-5-fluoroacetophenone crystallization mother liquor 浙江工业大学 2024-02-02 — — CN claimed
CN-117402055-A Resource utilization method of 2, 4-dichloro-5-fluoroacetophenone mother liquor 浙江吉泰新材料股份有限公司 2024-01-16 — — CN claimed
CN-106892803-B Preparation method of 2, 6-dichloro-3-fluorobenzaldehyde and preparation method of fluoroquinolone compound 浙江朗华制药有限公司 2020-08-14 — — CN claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 — — US claimed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 — — US claimed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 — — US claimed
US-20060020141-A1 Metallized dye XEROX CORPORATION 2006-01-26 — — US claimed
US-20060016369-A1 PHASE CHANGE INKS XEROX CORPORATION 2006-01-26 — — US claimed
US-6946025-B2 Process for preparing tetra-amide compounds XEROX CORPORATION (US) 2005-09-20 — — US claimed
US-20050090690-A1 Process for preparing tetra-amide compounds XEROX CORPORATION 2005-04-28 — — US claimed
EP-0355774-B1 Nucleus-fluorinated aromatic carboxylates and processes for their production ASAHI GLASS CO LTD (JP) 1995-04-26 — — EP claimed
US-4985588-A Nucleus-fluorinated aromatic carboxylates and processes for their production ASAHI GLASS COMPANY LTD. (JP) 1991-01-15 — — US claimed
EP-0355774-A2 Nucleus-fluorinated aromatic carboxylates and processes for their production ASAHI GLASS COMPANY LTD. (JP) 1990-02-28 — — EP claimed
EP-0176026-B1 PROCESS FOR THE PREPARATION OF 2,4-DICHLORO-5-FLUORO-BENZOIC ACID BAYER AG (DE) 1987-11-25 — — EP claimed
EP-0176026-A1 Process for the preparation of 2,4-dichloro-5-fluoro-benzoic acid BAYER AG (DE) 1986-04-02 — — EP claimed
US-4439620-A CHEMICAL INTERMEDIATE BAYER AKTIENGESELLSCHAFT (DE) 1984-03-27 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS KEAP1 3106/4885NFE2L2 4821/4885CA12 4479/4885
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS KEAP1 3106/4885NFE2L2 4821/4885CA12 4479/4885
US-20060020141-A1 Metallized dye CDYL, CDY1; CDY1B, CDYL2 KEAP1 1864/4885NFE2L2 1266/4885CA12 22/4885
US-20050090690-A1 Process for preparing tetra-amide compounds TAF9, TAF5, TAF1 KEAP1 2845/4885NFE2L2 3435/4885CA12 891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.