Sugi Predict

Sugi Predict / Compounds / SCHEMBL223134

SCHEMBL223134

SCHEMBL223134

O=C(O)c1cc(F)c(Cl)cc1F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.53
▸ NFE2L2 Q16236 1/20 0.53
▸ KDM4E B2RXH2 1/20 0.44
▸ ASPH Q12797 1/20 0.44
▸ KDM8 Q8N371 1/20 0.44
▸ TSHR P16473 3/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ TP53 P04637 1/20 0.43
▸ CASP1 P29466 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ POLB P06746 1/20 0.43
▸ APEX1 P27695 1/20 0.43
▸ GPR27 Q9NS67 1/20 0.42
▸ AKR1C4 P17516 1/20 0.42
▸ AKR1C3 P42330 1/20 0.42
▸ AKR1C2 P52895 1/20 0.42
▸ AKR1C1 Q04828 1/20 0.42
▸ PYGL P06737 1/20 0.42
▸ HPGD P15428 2/20 0.42
▸ ALPL P05186 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29488312 0.91 KEAP1 (0.48) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL363365 0.91 KEAP1 (0.48) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL6657490 0.90 KEAP1 (0.46) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL31586627 0.88 KEAP1 (0.55) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL14331830 0.88 KEAP1 (0.50) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL27617055 0.87 KEAP1 (0.50) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL221449 0.86 KEAP1 (0.53) KEAP1NFE2L2KDM4ETSHRALDH1A1
SCHEMBL364382 0.86 KEAP1 (0.48) KEAP1NFE2L2KDM4EASPHKDM8
SCHEMBL1713733 0.85 KDM4E (0.54) KEAP1NFE2L2KDM4EASPHKDM8
Hydrochloric Acid SCHEMBL11043790 0.84 KEAP1 (0.52) KEAP1NFE2L2KDM4ETSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 288 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4661890-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS Purdue Research Foundation (US) 2025-12-17 — — EP claimed
WO-2024167565-A1 PTP1B/TC-PTP DUAL INHIBITORS AND PROTEIN DEGRADERS PURDUE RESEARCH FOUNDATION (US) 2024-08-15 — — WO claimed
CN-107681052-B Main group metal complexes as p-dopants for organic electronic matrix materials 西门子公司 2020-03-24 — — CN claimed
US-10483466-B2 P-doping cross-linking of organic hole transporters SIEMENS AKTIENGESELLSCHAFT (DE) 2019-11-19 — — US claimed
EP-3114715-B1 P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS SIEMENS AG (DE) 2019-10-30 — — EP claimed
US-10072043-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2018-09-11 — — US claimed
US-20180198069-A1 P-Doping Cross-Linking Of Organic Hole Transporters SIEMENS AKTIENGESELLSCHAFT (DE) 2018-07-12 — — US claimed
EP-3057151-B1 BISMUTH AND TIN COMPLEXES AS P DOTANDS FOR ORGANIC ELECTRONIC MATRIX MATERIALS SIEMENS AG (DE) 2018-01-31 — — EP claimed
US-20170098787-A1 MAIN GROUP METAL COMPLEXES AS P-DOPANTS FOR ORGANIC ELECTRONIC MATRIX MATERIALS SIEMENS AKTIENGESELLSCHAFT (DE) 2017-04-06 — — US claimed
EP-3114715-A1 P-DOPING CROSS-LINKING OF ORGANIC HOLE TRANSPORTERS Siemens Aktiengesellschaft (DE) 2017-01-11 — — EP claimed
EP-3057151-A1 PRINCIPAL GROUP METAL COMPLEXES AS P DOTANDS FOR ORGANIC ELECTRONIC MATRIX MATERIALS Siemens Aktiengesellschaft (DE) 2016-08-17 — — EP claimed
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES Indiana University Research and Technology Corpora tion (US) 2016-06-23 — — US claimed
US-9217012-B2 Inhibitors of protein tyrosine phosphatases INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-12-22 — — US claimed
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATI (US) 2012-04-12 — — US claimed
WO-2010118241-A2 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) 2010-10-14 — — WO claimed
US-4996355-A Novel intermediates for the production of 2,4,5-trifluorobenzoyl fluoride MALLINCKRODT, INC. (US) 1991-02-26 — — US claimed
WO-1990012780-A1 INTERMEDIATES FOR THE PRODUCTION OF 2,4,5-TRIFLUORBENZOYL FLUORIDE MALLINCKRODT, INC. (US) 1990-11-01 — — WO claimed
JP-6157548-A — — None — — JP disclosed
EP-0411252-A1 Process for the preparation of fluorobenzoic acids RIEDEL-DE HAEN AKTIENGESELLSCHAFT (DE) 1991-02-06 — — EP disclosed
WO-1990012780-A1 INTERMEDIATES FOR THE PRODUCTION OF 2,4,5-TRIFLUORBENZOYL FLUORIDE MALLINCKRODT, INC. (US) 1990-11-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10072043-B2 Inhibitors of protein tyrosine phosphatases PTPRCAP, PTPRF, PTPRS KEAP1 3106/4885NFE2L2 4821/4885KDM4E 2134/4885
US-20170098787-A1 MAIN GROUP METAL COMPLEXES AS P-DOPANTS FOR ORGANIC ELECTRONIC MATRIX MATERIALS SCO2, SOD3, NCOA3 KEAP1 907/4885NFE2L2 242/4885KDM4E 1107/4885
US-20160176922-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS KEAP1 3106/4885NFE2L2 4821/4885KDM4E 2134/4885
US-20120088720-A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES PTPRCAP, PTPRF, PTPRS KEAP1 3106/4885NFE2L2 4821/4885KDM4E 2134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.