Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 1.00 |
| ▸ | RAF1 | P04049 | 4/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.60 |
| ▸ | GCGR | P47871 | 2/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7643418 | 0.85 | BRAF (1.00) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL29355176 | 0.85 | BRAF (1.00) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| Bromide SCHEMBL7648283 | 0.83 | BRAF (0.95) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL7648286 | 0.81 | BRAF (0.91) | BRAFRAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL12856388 | 0.81 | BRAF (0.90) | BRAFRAF1ALOX5MAPK14MAPK13 | |
| SCHEMBL7236344 | 0.80 | ALOX5 (0.79) | BRAFRAF1ALOX5MAPK14MAPK13 | |
| SCHEMBL16511391 | 0.80 | ALOX5 (0.79) | BRAFRAF1ALOX5MAPK14MAPK13 | |
| SCHEMBL4553281 | 0.79 | ALOX5 (1.00) | BRAFRAF1ALOX5MAPK14MAPK13 | |
| SCHEMBL6465062 | 0.79 | ALOX5 (1.00) | BRAFRAF1ALOX5MAPK14MAPK13 | |
| SCHEMBL28017623 | 0.77 | MAPK13 (0.66) | BRAFRAF1ALOX5MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2447266-B1 | Pyrimidopyridine compound used as a CSBP/RK/p38 modulator | GLAXO GROUP LTD (GB) | 2013-06-12 | — | — | EP | disclosed |
| US-8354416-B2 | 3-[2-{[3-(diethylamino)propyl]amino}-8-(2,6-difluorophenyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-5-fluoro-4-methyl-N-(1-methylethyl)benzamide; treating CSBP/p38 kinase mediated diseases; cytokine suppressive anti-inflammatory drugs; mitogen-activated protein kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2013-01-15 | — | — | US | disclosed |
| EP-1654235-B1 | 3- AMINOCARBONYL, 6-PHENYL SUBSTITUTED PYRIDINE-1-OXIDES AS P38 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-1868611-B1 | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES | GLAXO GROUP LTD (GB) | 2012-11-14 | — | — | EP | disclosed |
| CN-102746299-A | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-102746300-A | 8-phenyl-7,8-dihydropyridines[2,3-d]pyrimidine-7-ketone and uses as medicament | GLAXO GROUP LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-102746301-A | 8-phenyl-7,8-dihydropyrido[2,3-d]pyrimidin-7-ones and their use as pharmaceuticals | GLAXO GROUP LTD | 2012-10-24 | — | — | CN | disclosed |
| US-8207176-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2012-06-26 | — | — | US | disclosed |
| EP-2447266-A1 | Pyrimidopyridine compound used as a CSBP/RK/p38 modulator | GLAXO GROUP LIMITED (GB) | 2012-05-02 | — | — | EP | disclosed |
| CN-101184758-B | Novel compounds | GLAXO GROUP LTD | 2012-05-02 | — | — | CN | disclosed |
| EP-1261602-A1 | IMIDAZOL-2-CARBOXAMIDE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2002-12-04 | — | — | EP | disclosed |
| WO-2002094808-A1 | IMIDAZOLE-2-CARBOXAMIDE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-11-28 | — | — | WO | disclosed |
| EP-1257543-A1 | PYRIDINYLIMIDAZOLES | SMITHKLINE BEECHAM PLC (GB) | 2002-11-20 | — | — | EP | disclosed |
| EP-1232153-A2 | IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2002-08-21 | — | — | EP | disclosed |
| WO-2002055077-A1 | USE OF IMIDAZOLYL CYCLIC ACETAL DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF DISEASES MEDIATED BY THE ALK5 RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-18 | — | — | WO | disclosed |
| WO-2002024680-A1 | IMIDAZOLE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-03-28 | — | — | WO | disclosed |
| WO-2001072737-A1 | TRIARYLIMIDAZOLE DERIVATIVES AS CYTOKINE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2001066540-A1 | IMIDAZOL-2-CARBOXAMIDE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-09-13 | — | — | WO | disclosed |
| WO-2001062756-A1 | PYRIDINYLIMIDAZOLES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-30 | — | — | WO | disclosed |
| WO-2001038324-A2 | IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-31 | — | — | WO | disclosed |